Source:http://linkedlifedata.com/resource/pubmed/id/19121610
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2009-5-5
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| pubmed:abstractText |
The easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lactide-co-glycolide) and amorphous tricalcium phosphate nanoparticles (PLGA/TCP 60:40). Immersion in simulated body fluid showed exceptional in vitro bioactivity for TCP-containing fibres (mass gain: 18%, 2 days, HAp deposition). Bone regeneration was quantitatively investigated by creating four circular non-critical-size calvarial defects in New Zealand White rabbits. The defects were filled with the easy applicable cottonwool-like PLGA/TCP fibres or PLGA alone. Porous bovine-derived mineral (Bio-Oss) was used as a positive control and cavities left empty served as a negative control. The area fraction of newly formed bone (4 weeks implantation) was significantly increased for TCP-containing fibres compared to pure PLGA (histological and micro-computed tomographic analysis). A spongiosa-like structure of the newly formed bone tissue was observed for PLGA/TCP nanocomposites, whereas Bio-Oss-treated defects afforded a solid cortical bone.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Polyglycolic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/polylactic acid-polyglycolic acid...,
http://linkedlifedata.com/resource/pubmed/chemical/tricalcium phosphate
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1878-7568
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1775-84
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| pubmed:meshHeading |
pubmed-meshheading:19121610-Animals,
pubmed-meshheading:19121610-Biocompatible Materials,
pubmed-meshheading:19121610-Body Fluids,
pubmed-meshheading:19121610-Bone Substitutes,
pubmed-meshheading:19121610-Calcification, Physiologic,
pubmed-meshheading:19121610-Calcium Phosphates,
pubmed-meshheading:19121610-Cotton Fiber,
pubmed-meshheading:19121610-Lactic Acid,
pubmed-meshheading:19121610-Materials Testing,
pubmed-meshheading:19121610-Microscopy, Electron, Scanning,
pubmed-meshheading:19121610-Nanocomposites,
pubmed-meshheading:19121610-Osteogenesis,
pubmed-meshheading:19121610-Pliability,
pubmed-meshheading:19121610-Polyglycolic Acid,
pubmed-meshheading:19121610-Rabbits,
pubmed-meshheading:19121610-Skull,
pubmed-meshheading:19121610-Temperature,
pubmed-meshheading:19121610-Tissue Scaffolds,
pubmed-meshheading:19121610-X-Ray Microtomography
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| pubmed:year |
2009
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| pubmed:articleTitle |
In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects.
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| pubmed:affiliation |
Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, ETH Zurich, 8093 Zurich, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|