Linked Life Data

19120472

Source:http://linkedlifedata.com/resource/pubmed/id/19120472

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-5
pubmed:abstractText
The class A scavenger receptors are phagocytic pattern recognition receptors that are well represented in vertebrate genomes. The high level of conservation among vertebrates implies that this is an evolutionarily conserved family of receptors and indicates the presence of a common ancestral gene. The identity of this ancestral gene is not clear, as it appears that many of the domains of the scavenger receptors (e.g. collagenous, scavenger receptor cysteine rich) originated early in evolutionary history and are found in many combinations, often in genes of unknown function. These early receptors may function in cell-cell recognition, aggregation, or lipid recognition, and their involvement in pattern recognition, phagocytosis, and homeostasis may have been adaptations of such conserved patterns. Herein, we reclassify the class A scavenger receptors based on recent discoveries of new members of this family, describe the evolution of the various domains of the class A scavenger receptors, and discuss the appearance and function of these domains through evolutionary history.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1600-065X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
227
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-31
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Conserved domains of the class A scavenger receptors: evolution and function.
pubmed:affiliation
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't