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rdf:type |
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lifeskim:mentions |
umls-concept:C0001811,
umls-concept:C0032169,
umls-concept:C0231337,
umls-concept:C0243072,
umls-concept:C0336791,
umls-concept:C0443239,
umls-concept:C0599883,
umls-concept:C1292733,
umls-concept:C1527148,
umls-concept:C1705848,
umls-concept:C2728259
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pubmed:issue |
12
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pubmed:dateCreated |
2009-1-5
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pubmed:abstractText |
Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1608-3040
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pubmed:author |
pubmed-author:AnisimovV NVN,
pubmed-author:BakeevaL ELE,
pubmed-author:EgorminP APA,
pubmed-author:FilenkoO FOF,
pubmed-author:IsakovaE FEF,
pubmed-author:ManskikhV NVN,
pubmed-author:MikhelsonV MVM,
pubmed-author:PanteleevaA AAA,
pubmed-author:PasyukovaE GEG,
pubmed-author:PilipenkoD IDI,
pubmed-author:PiskunovaT STS,
pubmed-author:PopovichI GIG,
pubmed-author:RoshchinaN VNV,
pubmed-author:RybinaO YuOY,
pubmed-author:SamoylovaT ATA,
pubmed-author:SaprunovaV BVB,
pubmed-author:SemenchenkoA VAV,
pubmed-author:SkulachevM VMV,
pubmed-author:SkulachevV PVP,
pubmed-author:SpivakI MIM,
pubmed-author:Tsybul'koE AEA,
pubmed-author:TyndykM LML,
pubmed-author:VyssokikhM YuMY,
pubmed-author:YurovaM NMN,
pubmed-author:ZabezhinskyM AMA
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pubmed:issnType |
Electronic
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1329-42
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pubmed:meshHeading |
pubmed-meshheading:19120018-Aging,
pubmed-meshheading:19120018-Animals,
pubmed-meshheading:19120018-Biological Transport,
pubmed-meshheading:19120018-Cells, Cultured,
pubmed-meshheading:19120018-Cladocera,
pubmed-meshheading:19120018-Drosophila melanogaster,
pubmed-meshheading:19120018-Female,
pubmed-meshheading:19120018-Fibroblasts,
pubmed-meshheading:19120018-Longevity,
pubmed-meshheading:19120018-Male,
pubmed-meshheading:19120018-Mice,
pubmed-meshheading:19120018-Mice, Transgenic,
pubmed-meshheading:19120018-Mitochondria,
pubmed-meshheading:19120018-Plastoquinone,
pubmed-meshheading:19120018-Podospora
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pubmed:year |
2008
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pubmed:articleTitle |
Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence.
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pubmed:affiliation |
Petrov Institute of Oncology, St. Petersburg, 197758, Russia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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