rdf:type |
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0025202,
umls-concept:C0030705,
umls-concept:C0332206,
umls-concept:C0332448,
umls-concept:C0439662,
umls-concept:C1332802,
umls-concept:C1416433,
umls-concept:C1416467,
umls-concept:C1517564,
umls-concept:C1564138
|
pubmed:issue |
1
|
pubmed:dateCreated |
2009-1-1
|
pubmed:abstractText |
CTL-associated antigen 4 (CTLA4)-blocking monoclonal antibodies induce long-term regression of metastatic melanoma in some patients, but the exact mechanism is unknown. In this study, biopsies of selected accessible tumor lesions from patients treated with tremelimumab were examined to further elucidate the mechanism of its antitumor activity.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CP-675,206,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Indoleamine-Pyrrole 2,3,-Dioxygenase
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1078-0432
|
pubmed:author |
pubmed-author:BewL KLK,
pubmed-author:CochranAlistair JAJ,
pubmed-author:Comin-AnduixBegoñaB,
pubmed-author:DissetteVivian BVB,
pubmed-author:DonahueTimothy RTR,
pubmed-author:EconomouJames SJS,
pubmed-author:GlaspyJohn AJA,
pubmed-author:Gomez-NavarroJesusJ,
pubmed-author:MorrisLilah FLF,
pubmed-author:RibasAntoniA,
pubmed-author:ShintakuItsushi PeterIP,
pubmed-author:de la RochaPilarP
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
15
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
390-9
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:19118070-Adult,
pubmed-meshheading:19118070-Aged,
pubmed-meshheading:19118070-Aged, 80 and over,
pubmed-meshheading:19118070-Antibodies, Monoclonal,
pubmed-meshheading:19118070-Antigens, CD,
pubmed-meshheading:19118070-Biopsy,
pubmed-meshheading:19118070-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19118070-CTLA-4 Antigen,
pubmed-meshheading:19118070-Female,
pubmed-meshheading:19118070-Forkhead Transcription Factors,
pubmed-meshheading:19118070-Humans,
pubmed-meshheading:19118070-Indoleamine-Pyrrole 2,3,-Dioxygenase,
pubmed-meshheading:19118070-Male,
pubmed-meshheading:19118070-Melanoma,
pubmed-meshheading:19118070-Middle Aged,
pubmed-meshheading:19118070-T-Lymphocytes, Cytotoxic
|
pubmed:year |
2009
|
pubmed:articleTitle |
Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade.
|
pubmed:affiliation |
Division of Hematology/Oncology, Department of Medicine, University of California-Los Angeles, Los Angeles, California 90095-1782, USA. aribas@mednet.ucla.edu
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|