Linked Life Data

19117981

Source:http://linkedlifedata.com/resource/pubmed/id/19117981

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-1-1
pubmed:abstractText
To search for genetic variants that are associated with prostate cancer risk in the genome, we combined the data from our genome-wide association study (GWAS) in a population-based case-control study in Sweden with publicly available GWAS data from the Cancer Genetic Markers of Susceptibility (CGEMS) study. We limited the cases to those with aggressive disease in an attempt to identify risk variants that are associated with this most clinically relevant form of the disease. Among the most likely candidate single nucleotide polymorphisms (SNP) identified from the two GWAS, we sequentially confirmed one SNP at 22q13 in two independent study populations: the remaining subjects in Cancer of the Prostate in Sweden and a hospital-based case-control study at Johns Hopkins Hospital. Association of aggressive prostate cancer with the SNP at 22q13 was also observed in the publicly available data of four additional study populations from the second stage of the CGEMS study. In all seven study populations examined, the frequency of allele "C" of rs9623117 at 22q13 was consistently higher in aggressive cases than in controls. The combined allelic test was highly significant, with P = 5.0 x 10(-7). The odds ratio (OR) of allele C for aggressive prostate cancer was estimated to be 1.18 [95% confidence interval (95% CI), 1.11-1.26]. However, the SNP was also associated with nonaggressive prostate cancer, with an estimated OR of 1.11 (95% CI, 1.04-1.19; P = 0.004). The risk-associated variants are located within the genomic region of TNRC6B, a gene involved in miRNA-mediated mRNA degradation. Additional studies are warranted to further confirm the association.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-15988677, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-16289642, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-16682969, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-16945910, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-17401363, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-17401366, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-17478474, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-17572673, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-17603485, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-17925536, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18066601, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18073375, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18199855, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18264096, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18264097, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18264098, http://linkedlifedata.com/resource/pubmed/commentcorrection/19117981-18491292
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1538-7445
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-5
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Sequence variants at 22q13 are associated with prostate cancer risk.
pubmed:affiliation
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural