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pubmed-article:19116668pubmed:abstractTextLocalising regulatory variants that control gene expression is a challenge for genome research. Several studies have recently identified non-coding polymorphisms associated with inter-individual differences in gene expression. These approaches rely on the identification of signals of association against a background of variation due to other genetic and environmental factors. A complementary approach is to use an Allele-Specific Expression (ASE) assay, which is more robust to the effects of environmental variation and trans-acting genetic factors.lld:pubmed
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pubmed-article:19116668pubmed:articleTitleValidating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations.lld:pubmed
pubmed-article:19116668pubmed:affiliationWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. sc11@sanger.ac.uklld:pubmed
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