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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0017262,
umls-concept:C0032659,
umls-concept:C0185117,
umls-concept:C0185125,
umls-concept:C0205369,
umls-concept:C0205419,
umls-concept:C0220905,
umls-concept:C0314603,
umls-concept:C0449445,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-31
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pubmed:abstractText |
Localising regulatory variants that control gene expression is a challenge for genome research. Several studies have recently identified non-coding polymorphisms associated with inter-individual differences in gene expression. These approaches rely on the identification of signals of association against a background of variation due to other genetic and environmental factors. A complementary approach is to use an Allele-Specific Expression (ASE) assay, which is more robust to the effects of environmental variation and trans-acting genetic factors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-12567189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-12627232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-14574645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-14685227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-15049300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-15269782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-15338642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-15499010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-16251966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-16301213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-16362079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-16909391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-17135570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-17206142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-17873874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19116668-18200594
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:AuburnSarahS,
pubmed-author:CampinoSusanaS,
pubmed-author:ClarkTaane GTG,
pubmed-author:FortonJulianJ,
pubmed-author:FryAndrewA,
pubmed-author:KwiatkowskiDominic PDP,
pubmed-author:ManganoValentina DVD,
pubmed-author:MohrBertB,
pubmed-author:RajSrilakshmiS,
pubmed-author:RichardsonAnnaA,
pubmed-author:RockettKirkK,
pubmed-author:VandiedonckClaireC
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e4105
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19116668-Alleles,
pubmed-meshheading:19116668-Chromosome Mapping,
pubmed-meshheading:19116668-Gene Expression Regulation,
pubmed-meshheading:19116668-Genetic Variation,
pubmed-meshheading:19116668-Genome, Human,
pubmed-meshheading:19116668-Genomics,
pubmed-meshheading:19116668-Haplotypes,
pubmed-meshheading:19116668-Humans,
pubmed-meshheading:19116668-Polymorphism, Single Nucleotide,
pubmed-meshheading:19116668-Regulatory Sequences, Nucleic Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations.
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pubmed:affiliation |
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. sc11@sanger.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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