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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-2
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pubmed:abstractText |
G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-10769386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-10896954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-10938112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-11069976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-11378178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-11896197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-11926716,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-12611588,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-12695502,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-15800193,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-17565117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-17713528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-17898223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-18156102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-2858080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-3923523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-7267400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-7855188,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19114090-9826657
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
451
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-61
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pubmed:dateRevised |
2010-9-22
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pubmed:meshHeading |
pubmed-meshheading:19114090-Animals,
pubmed-meshheading:19114090-Anxiety Disorders,
pubmed-meshheading:19114090-Brain,
pubmed-meshheading:19114090-Brain Chemistry,
pubmed-meshheading:19114090-Cell Cycle Proteins,
pubmed-meshheading:19114090-Depressive Disorder,
pubmed-meshheading:19114090-Disease Models, Animal,
pubmed-meshheading:19114090-Female,
pubmed-meshheading:19114090-Male,
pubmed-meshheading:19114090-Maze Learning,
pubmed-meshheading:19114090-Mice,
pubmed-meshheading:19114090-Mice, Knockout,
pubmed-meshheading:19114090-Neuropsychological Tests,
pubmed-meshheading:19114090-Phosphoproteins,
pubmed-meshheading:19114090-Sex Characteristics,
pubmed-meshheading:19114090-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Anxiety-like behaviors in mice lacking GIT2.
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pubmed:affiliation |
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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