Source:http://linkedlifedata.com/resource/pubmed/id/19111574
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2009-2-13
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| pubmed:abstractText |
CD4(+)CD25(+) regulatory T cells (CD4(+)CD25(+) Tregs) play a critical role in the maintenance of peripheral self-tolerance and the regulation of immune responses. Genetic defects that primarily affect the development and/or function of CD4(+)CD25(+) Tregs result in severe autoimmune diseases and inflammatory disorders. In this study, we investigated whether the peripheral pool and the function of CD4(+)CD25(+) Tregs are altered in patients of myasthenia gravis (MG), a chronic autoimmune disorder that results in progressive skeletal muscle weakness. Here we showed that both mRNA and protein expression level of FoxP3 in CD4(+)CD25(+) Tregs are dramatically down-regulated, accompanied by an severe functional defect in CD4(+)CD25(+) Tregs regulatory activity when cocultured with autologous CD4(+)CD25(-) T cells, although the reservoir of CD4(+)CD25(+) Tregs is not changed in peripheral blood from MG patients. Since FoxP3 is a pivotal transcription factor that indispensable for the generation and the regulatory function of CD4(+)CD25(+) Tregs, our data suggested that the functional activity of CD4(+)CD25(+) Tregs is inhibited in MG patients and that MG might originate from the dysfunction of CD4(+)CD25(+) Tregs. Although the underlying molecular basis for the reduced expression of FoxP3 in CD4(+)CD25(+) Tregs from MG patients remains unknown, this study provided a potential target for MG therapy.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
1879-0542
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
29
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
52-7
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| pubmed:meshHeading |
pubmed-meshheading:19111574-Adolescent,
pubmed-meshheading:19111574-Adult,
pubmed-meshheading:19111574-Aged,
pubmed-meshheading:19111574-Aged, 80 and over,
pubmed-meshheading:19111574-Antigens, CD4,
pubmed-meshheading:19111574-Cell Proliferation,
pubmed-meshheading:19111574-Child,
pubmed-meshheading:19111574-Coculture Techniques,
pubmed-meshheading:19111574-Down-Regulation,
pubmed-meshheading:19111574-Female,
pubmed-meshheading:19111574-Forkhead Transcription Factors,
pubmed-meshheading:19111574-Humans,
pubmed-meshheading:19111574-Immunosuppression,
pubmed-meshheading:19111574-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:19111574-Male,
pubmed-meshheading:19111574-Middle Aged,
pubmed-meshheading:19111574-Myasthenia Gravis,
pubmed-meshheading:19111574-T-Lymphocytes, Regulatory,
pubmed-meshheading:19111574-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
The role of FoxP3+CD4+CD25hi Tregs in the pathogenesis of myasthenia gravis.
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| pubmed:affiliation |
Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Helongjiang 150086, PR China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|