Linked Life Data

19110637

Source:http://linkedlifedata.com/resource/pubmed/id/19110637

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-12-26
pubmed:abstractText
Large animal models have played a crucial role in the development of gene therapy protocols. A significant advantage of large animal models over rodent models includes the ability to more easily translate protocols developed in large animals to humans. For gene therapy applications, nonhuman primates and canines have been the main large animal models. Canines have the advantage that there are disease models available, e.g., hemolytic anemia (pyruvate kinase deficiency), leukocyte adhesion deficiency, severe combined immunodeficiency (XSCID), storage diseases, and others. In addition, all three major integrating virus systems, i.e., gammaretrovirus-, HIV-derived lenti- and foamy virus vectors are able to efficiently transduce canine hematopoietic cells. Here we describe protocols developed for efficient transduction of canine hematopoietic repopulating cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
506
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-61
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Canine models of gene-modified hematopoiesis.
pubmed:affiliation
Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural