Linked Life Data

19109828

Source:http://linkedlifedata.com/resource/pubmed/id/19109828

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-30
pubmed:abstractText
Globins are generally considered as carriers of diatomic gaseous ligands (e.g., O(2) and NO) in metazoa. Recently, the (pseudo-)enzymatic activity of globins towards reactive nitrogen and oxygen species has been elucidated. In particular, some globins (e.g., hemoglobin and myoglobin) catalyze the enzymatic scavenging of NO and peroxynitrite in the presence of H(2)O(2). Indeed, H(2)O(2) oxidizes some globins leading to the formation of water and of the heme-protein ferryl derivative, which, in turn, oxidizes NO and peroxynitrite leading to the formation of the globin ferric species, NO(2)(-), and NO(3)(-). Here, we hypothesize that NO, peroxynitrite, and H(2)O(2) are co-substrates for the peroxidase activity of some globins, this catalytic activity was reported in 1900 for the first time, even though the substrates have never been identified firmly up to now.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1521-6551
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
62-73
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Catalytic peroxidation of nitrogen monoxide and peroxynitrite by globins.
pubmed:affiliation
Dipartimento di Biologia e Laboratorio Interdipartimentale di Microscopia Elettronica, Università Roma Tre, Roma, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't