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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
26
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pubmed:dateCreated |
2008-12-25
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pubmed:abstractText |
The myeloproliferative disorders are clonal disorders with frequent somatic gain-of-function alterations affecting tyrosine kinases. In these diseases, there is an increase in DNA damage and a risk of progression to acute leukemia. The molecular mechanisms in myeloproliferative disorders that prevent apoptosis induced by damaged DNA are obscure.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1533-4406
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pubmed:author |
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pubmed:copyrightInfo |
2008 Massachusetts Medical Society
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
359
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2778-89
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19109573-Apoptosis,
pubmed-meshheading:19109573-Cation Transport Proteins,
pubmed-meshheading:19109573-Cell Line, Tumor,
pubmed-meshheading:19109573-DNA Damage,
pubmed-meshheading:19109573-Deamination,
pubmed-meshheading:19109573-Fusion Proteins, bcr-abl,
pubmed-meshheading:19109573-Gene Transfer Techniques,
pubmed-meshheading:19109573-Genes, abl,
pubmed-meshheading:19109573-Humans,
pubmed-meshheading:19109573-Janus Kinase 2,
pubmed-meshheading:19109573-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:19109573-Leukocytes, Mononuclear,
pubmed-meshheading:19109573-Myeloproliferative Disorders,
pubmed-meshheading:19109573-Polycythemia Vera,
pubmed-meshheading:19109573-Protein-Tyrosine Kinases,
pubmed-meshheading:19109573-Signal Transduction,
pubmed-meshheading:19109573-Sodium-Hydrogen Antiporter,
pubmed-meshheading:19109573-bcl-X Protein
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders.
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pubmed:affiliation |
Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom. rui.zhao@bbsrc.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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