Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-2-20
pubmed:abstractText
Leukemias with MLL rearrangements are characterized by high expression of the homeobox gene MEIS1. In these studies, we knocked down Meis1 expression by shRNA lentivirus transduction in murine Mll-AF9 leukemia cells. Meis1 knockdown resulted in decreased proliferation and survival of murine Mll-AF9 leukemia cells. We also observed reduced clonogenic capacity and increased monocytic differentiation. The establishment of leukemia in transplantation recipients was significantly delayed by Meis1 knockdown. Gene expression profiling of cells transduced with Meis1 shRNA showed reduced expression of genes associated with cell cycle entry and progression. shRNA-mediated knockdown of MEIS1 in human MLL-fusion gene leukemia cell lines resulted in reduced cell growth. These results show that MEIS1 expression is important for MLL-rearranged leukemias and suggest that MEIS1 promotes cell-cycle entry. Targeting MEIS1 may have therapeutic potential for treating leukemias expressing this transcription factor.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-10393173, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-11007956, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-11731795, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-12086872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-12515728, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-12782787, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-12851482, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-14555522, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-14615372, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-14701735, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-15190208, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-15838524, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-17099226, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-17942707, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-18455126, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-20430967, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-2410069, http://linkedlifedata.com/resource/pubmed/commentcorrection/19109563-9250666
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1528-0020
pubmed:author
pubmed:issnType
Electronic
pubmed:day
19
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1756-8
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A role for MEIS1 in MLL-fusion gene leukemia.
pubmed:affiliation
Masonic Cancer Center, Minneapolis, MN 55455, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural