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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
52
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pubmed:dateCreated |
2008-12-25
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pubmed:abstractText |
The failure of the remyelination processes in multiple sclerosis contributes to the formation of chronic demyelinated plaques that lead to severe neurological deficits. Long-term cuprizone treatment of C57BL/6 mice resulted in pronounced white matter pathology characterized by oligodendrocyte depletion, irreversible demyelination and persistent functional deficits after cuprizone withdrawal. The use of a combination of in vivo diffusion tensor magnetic resonance imaging (DT-MRI) and histological analyses allowed for an accurate longitudinal assessment of demyelination. Injection of triiodothyronine (T(3)) hormone over a 3 week interval after cuprizone withdrawal progressively restored the normal DT-MRI phenotype accompanied by an improvement of clinical signs and remyelination. The effects of T(3) were not restricted to the later stages of remyelination but increased the expression of sonic hedgehog and the numbers of Olig2(+) and PSA-NCAM(+) precursors and proliferative cells. Our findings establish a role for T(3) as an inducer of oligodendrocyte progenitor cells in adult mouse brain following chronic demyelination.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonic Anhydrase II,
http://linkedlifedata.com/resource/pubmed/chemical/Cuprizone,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neural Cell Adhesion Molecule L1,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Shh protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sialic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine,
http://linkedlifedata.com/resource/pubmed/chemical/polysialyl neural cell adhesion...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1529-2401
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pubmed:author |
pubmed-author:AginArnaudA,
pubmed-author:BoehmNellyN,
pubmed-author:GhandourM SaidMS,
pubmed-author:GruckerDanielD,
pubmed-author:GuignardBlandineB,
pubmed-author:HarsanLaura-AdelaLA,
pubmed-author:MillerRobert HRH,
pubmed-author:ParizelNathalieN,
pubmed-author:PouletPatrickP,
pubmed-author:SapinRémyR,
pubmed-author:SteibelJérômeJ,
pubmed-author:ZarembaAnitaA
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14189-201
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pubmed:meshHeading |
pubmed-meshheading:19109501-Animals,
pubmed-meshheading:19109501-Antigens, CD45,
pubmed-meshheading:19109501-Brain Mapping,
pubmed-meshheading:19109501-Carbonic Anhydrase II,
pubmed-meshheading:19109501-Chronic Disease,
pubmed-meshheading:19109501-Cuprizone,
pubmed-meshheading:19109501-Demyelinating Diseases,
pubmed-meshheading:19109501-Diffusion Magnetic Resonance Imaging,
pubmed-meshheading:19109501-Disease Models, Animal,
pubmed-meshheading:19109501-Female,
pubmed-meshheading:19109501-Hedgehog Proteins,
pubmed-meshheading:19109501-Mice,
pubmed-meshheading:19109501-Mice, Inbred C57BL,
pubmed-meshheading:19109501-Microscopy, Electron, Transmission,
pubmed-meshheading:19109501-Myelin Sheath,
pubmed-meshheading:19109501-Nerve Tissue Proteins,
pubmed-meshheading:19109501-Neural Cell Adhesion Molecule L1,
pubmed-meshheading:19109501-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:19109501-Recovery of Function,
pubmed-meshheading:19109501-Sialic Acids,
pubmed-meshheading:19109501-Thyroid Hormones,
pubmed-meshheading:19109501-Time Factors,
pubmed-meshheading:19109501-Triiodothyronine
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pubmed:year |
2008
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pubmed:articleTitle |
Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging.
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pubmed:affiliation |
UMR 7191, Laboratoire d'Imagerie et de Neurosciences Cognitives, Faculté de Médecine, Université Louis Pasteur and Centre National de la Recherche Scientifique, 67085 Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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