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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020792,
umls-concept:C0086418,
umls-concept:C0597298,
umls-concept:C0597357,
umls-concept:C1155064,
umls-concept:C1167322,
umls-concept:C1171362,
umls-concept:C1424685,
umls-concept:C1515670,
umls-concept:C1710548,
umls-concept:C1880022,
umls-concept:C2752508
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-25
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pubmed:databankReference |
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pubmed:abstractText |
CD160 has been initially identified as a GPI-anchored MHC-class I activating receptor mainly expressed on peripheral blood NK cells. Herein, we report the identification of three additional CD160-related mRNAs generated through alternative splicings of the CD160 gene, among which one encoded a putative CD160 transmembrane isoform (CD160-TM). We first establish that CD160-TM surface expression is highly restricted to NK cells and is activation-dependent. Additionally, we provide evidence that CD160-TM represents a novel activating receptor, as assessed by the increased CD107a NK cell surface mobilization observed upon its engagement. Finally, we demonstrate that the CD160-TM cytoplasmic tail is by itself sufficient to mediate the recruitment of Erk1/2 signaling pathway, and that the initiation of this activation process is dependent on the Src-family kinase p56(lck). The identification of CD160-TM therefore provides new possibilities regarding the role of CD160 isoforms in the regulation of NK cell functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CD160 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1550-6606
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
182
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-71
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19109136-Amino Acid Sequence,
pubmed-meshheading:19109136-Antigens, CD,
pubmed-meshheading:19109136-Base Sequence,
pubmed-meshheading:19109136-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19109136-Cell Line,
pubmed-meshheading:19109136-Cell Line, Tumor,
pubmed-meshheading:19109136-Clone Cells,
pubmed-meshheading:19109136-G0 Phase,
pubmed-meshheading:19109136-GPI-Linked Proteins,
pubmed-meshheading:19109136-Gene Expression Regulation,
pubmed-meshheading:19109136-Humans,
pubmed-meshheading:19109136-Jurkat Cells,
pubmed-meshheading:19109136-Killer Cells, Natural,
pubmed-meshheading:19109136-Lymphocyte Activation,
pubmed-meshheading:19109136-Membrane Proteins,
pubmed-meshheading:19109136-Molecular Sequence Data,
pubmed-meshheading:19109136-Protein Isoforms,
pubmed-meshheading:19109136-RNA, Messenger,
pubmed-meshheading:19109136-Receptors, Immunologic
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pubmed:year |
2009
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pubmed:articleTitle |
Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.
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pubmed:affiliation |
Institeut National de la Santé et de la Recherche Médicale Unite 841, Department of Immunology, Université Paris 12, Faculté de Médecine de Créteil, Créteil, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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