19107805

Source:http://linkedlifedata.com/resource/pubmed/id/19107805

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004927, umls-concept:C0029418, umls-concept:C0115137, umls-concept:C0596995, umls-concept:C1707455
pubmed:issue	1
pubmed:dateCreated	2009-6-9
pubmed:abstractText	Surface topography is one of the most important surface properties of biomaterials and microfabrication techniques provide new routes to produce precisely controlled surface topographies for investigating the topographic effects on cell behavior. In this study, hydroxyapatite (HA) microgrooved surfaces were used to study the osteoblast and myoblast response to the surface micro-features. The microgrooves were first produced on silicon wafers by photolithography, and then coated with HA using sputtering technique. Orientation angle (OA) was used to evaluate the contact guidance introduced by microgrooves and form index (FI) was introduced to describe the cell morphology change. The results show that the microgroove effects on myoblasts are more obvious than those on osteoblasts, and the two types of cells are sensitive to different sizes of microgrooves. The microgrooves with 8 microm width strongly affect both osteoblasts and myoblasts, while the microgrooves with 24 microm width strongly affect myoblasts only. These results confirm that the surface topographic effect is of cell specific, and therefore, design of surface topographic features must be different for myoblasts and osteoblasts.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101234238
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Durapatite
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1552-4981
pubmed:author	pubmed-author:LengYangY, pubmed-author:LuXiongX
pubmed:copyrightInfo	(c) 2008 Wiley Periodicals, Inc.
pubmed:issnType	Electronic
pubmed:volume	90
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	438-45
pubmed:meshHeading	pubmed-meshheading:19107805-Durapatite, pubmed-meshheading:19107805-Microscopy, Electron, Scanning, pubmed-meshheading:19107805-Myoblasts, pubmed-meshheading:19107805-Osteoblasts
pubmed:year	2009
pubmed:articleTitle	Comparison of the osteoblast and myoblast behavior on hydroxyapatite microgrooves.
pubmed:affiliation	Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China. luxiong_2004@163.com
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't