Source:http://linkedlifedata.com/resource/pubmed/id/19107326
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2009-2-26
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| pubmed:abstractText |
The role of endoplasmic reticulum (ER) stress in kidney diseases is not well elucidated. Fifty patients with primary glomerular diseases (PGD): minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MGN), membranoproliferative glomerulonephritis (MPGN), and crescentic glomerulonephritis, n = 10 (each group) were enrolled. MCD, FSGS, and MGN patients were sub-grouped as nonproliferative glomerulonephritis (NPGN) and MPGN, RPGN as proliferative glomerulonephritis (PGN). Glucose regulated proteins (GRP-78), growth arrest and DNA damage inducible proteins (GADD-153), and Bcl-2 protein expression was analyzed by Western blotting, immunofluorescence and immunohistochemistry in the kidney biopsy. Up regulation of GADD-153, GRP-78, with more pronounced expression in PGN vs. NPGN (P < 0.05) and down regulation of Bcl-2 proteins was observed in the GN (PGD excluding MCD) as compared to MCD (P < 0.05). Our results suggest that renal injury in PGD is associated with ER stress and ER stress may be involved in the rapid progression of PGN to renal failure.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DDIT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor CHOP,
http://linkedlifedata.com/resource/pubmed/chemical/molecular chaperone GRP78
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1573-4919
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
324
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
131-8
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:19107326-Adolescent,
pubmed-meshheading:19107326-Adult,
pubmed-meshheading:19107326-Disease Progression,
pubmed-meshheading:19107326-Endoplasmic Reticulum,
pubmed-meshheading:19107326-Female,
pubmed-meshheading:19107326-Gene Expression Regulation,
pubmed-meshheading:19107326-Glomerulonephritis,
pubmed-meshheading:19107326-Glomerulonephritis, Membranoproliferative,
pubmed-meshheading:19107326-Glomerulonephritis, Membranous,
pubmed-meshheading:19107326-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:19107326-Heat-Shock Proteins,
pubmed-meshheading:19107326-Humans,
pubmed-meshheading:19107326-Kidney Glomerulus,
pubmed-meshheading:19107326-Male,
pubmed-meshheading:19107326-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19107326-Renal Insufficiency,
pubmed-meshheading:19107326-Transcription Factor CHOP,
pubmed-meshheading:19107326-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Up regulation of the GRP-78 and GADD-153 and down regulation of Bcl-2 proteins in primary glomerular diseases: a possible involvement of the ER stress pathway in glomerulonephritis.
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| pubmed:affiliation |
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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| pubmed:publicationType |
Journal Article
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