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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2008-12-24
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pubmed:abstractText |
Early diagnosis and appropriate treatment with intravitreous antibiotics are the most important factors for the successful management of endophthalmitis. The intraocular concentration of antibiotics after intravitreous injection is far greater than that achieved by any other modality. The organisms in postoperative endophthalmitis are usually Gram-positive cocci and less commonly Gram-negative bacteria. Drug combinations are necessary to cover the full range of bacteria causing endophthalmitis. Vancomycin (1 mg/0.1 ml) is considered the drug of choice for Gram-positive organisms. Controversy remains concerning the best choice against Gram-negative bacteria. Aminoglycosides (amikacin, 0.4 mg/0.1 ml) have traditionally been recommended for Gram-negative coverage. However, because of their possible role in macular toxicity, recent trends have shifted to using ceftazidime (2.25 mg/0.1 ml) in combination with vancomycin.
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pubmed:language |
fre
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1773-0597
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
815-23
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pubmed:meshHeading |
pubmed-meshheading:19107050-Aminoglycosides,
pubmed-meshheading:19107050-Animals,
pubmed-meshheading:19107050-Anti-Bacterial Agents,
pubmed-meshheading:19107050-Anti-Inflammatory Agents,
pubmed-meshheading:19107050-Blood-Retinal Barrier,
pubmed-meshheading:19107050-Cephalosporins,
pubmed-meshheading:19107050-Combined Modality Therapy,
pubmed-meshheading:19107050-Drug Therapy, Combination,
pubmed-meshheading:19107050-Endophthalmitis,
pubmed-meshheading:19107050-Fluoroquinolones,
pubmed-meshheading:19107050-Glycopeptides,
pubmed-meshheading:19107050-Gram-Negative Bacterial Infections,
pubmed-meshheading:19107050-Gram-Positive Bacterial Infections,
pubmed-meshheading:19107050-Half-Life,
pubmed-meshheading:19107050-Humans,
pubmed-meshheading:19107050-Injections,
pubmed-meshheading:19107050-Retinal Detachment,
pubmed-meshheading:19107050-Vancomycin,
pubmed-meshheading:19107050-Vitrectomy,
pubmed-meshheading:19107050-Vitreous Body
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pubmed:year |
2008
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pubmed:articleTitle |
[Intravitreal injection of antibiotics in endophthalmitis].
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pubmed:affiliation |
Service d'ophtalmologie, Hospices civils de Lyon, Hôpital E. Herriot, Université Lyon I, Lyon.
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pubmed:publicationType |
Journal Article,
English Abstract
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