19106084

Source:http://linkedlifedata.com/resource/pubmed/id/19106084

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0010762, umls-concept:C0070166, umls-concept:C0871261, umls-concept:C1704632, umls-concept:C1706817, umls-concept:C1882417, umls-concept:C2911692
pubmed:issue	4
pubmed:dateCreated	2009-1-23
pubmed:databankReference	http://linkedlifedata.com/resource/pubmed/xref/ClinicalTrials.gov/NCT00097591
pubmed:abstractText	Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles conferring reduced function.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/19106084-19164193, http://linkedlifedata.com/resource/pubmed/commentcorrection/19106084-19458375
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0255562
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Ticlopidine, http://linkedlifedata.com/resource/pubmed/chemical/clopidogrel
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	1533-4406
pubmed:author	pubmed-author:AntmanElliott MEM, pubmed-author:BrandtJohn TJT, pubmed-author:BraunwaldEugeneE, pubmed-author:CloseSandra LSL, pubmed-author:HockettRichard DRD, pubmed-author:MaciasWilliamW, pubmed-author:MegaJessica LJL, pubmed-author:SabatineMarc SMS, pubmed-author:ShenLeiL, pubmed-author:WalkerJoseph RJR, pubmed-author:WiviottStephen DSD
pubmed:copyrightInfo	2009 Massachusetts Medical Society
pubmed:issnType	Electronic
pubmed:day	22
pubmed:volume	360
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	354-62
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:19106084-Acute Coronary Syndrome, pubmed-meshheading:19106084-Adult, pubmed-meshheading:19106084-Angioplasty, Balloon, Coronary, pubmed-meshheading:19106084-Area Under Curve, pubmed-meshheading:19106084-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:19106084-Cardiovascular Diseases, pubmed-meshheading:19106084-Combined Modality Therapy, pubmed-meshheading:19106084-Female, pubmed-meshheading:19106084-Genotype, pubmed-meshheading:19106084-Heterozygote, pubmed-meshheading:19106084-Humans, pubmed-meshheading:19106084-Male, pubmed-meshheading:19106084-Mutation, pubmed-meshheading:19106084-Platelet Aggregation, pubmed-meshheading:19106084-Platelet Aggregation Inhibitors, pubmed-meshheading:19106084-Polymorphism, Genetic, pubmed-meshheading:19106084-Randomized Controlled Trials as Topic, pubmed-meshheading:19106084-Stents, pubmed-meshheading:19106084-Thrombosis, pubmed-meshheading:19106084-Ticlopidine
pubmed:year	2009
pubmed:articleTitle	Cytochrome p-450 polymorphisms and response to clopidogrel.
pubmed:affiliation	Thrombolysis in Myocardial Infarction Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. jmega@partners.org
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't