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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-8
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pubmed:abstractText |
This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromimetic T-0681 on lipoprotein metabolism and the development of atherosclerosis. Prolonged treatment with T-0681 increased the hepatic expression of both LDL receptor and scavenger receptor class B, type I without affecting cholesteryl ester transfer protein activity. Upregulation of hepatic lipoprotein receptors was accompanied by a marked decrease of apolipoprotein B-containing lipoproteins, reflected by a 60% reduction of plasma cholesterol and a >70% reduction of plasma triglyceride levels. Most importantly, T-0681 reduced the development of atherosclerosis by 80% in NZW rabbits on high-cholesterol chow. Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-11278882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-11588946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-12034052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-12093886,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-12746448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-12888625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-14595001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-15034639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-15572044,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-16133421,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19106072-9712728
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-2275
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pubmed:author |
pubmed-author:AuerKristinaK,
pubmed-author:DemetzEgonE,
pubmed-author:DuwenseeKristinaK,
pubmed-author:EllerPhilippP,
pubmed-author:FievetCatherineC,
pubmed-author:FoegerBernhardB,
pubmed-author:HoeferJuliaJ,
pubmed-author:HuberEvaE,
pubmed-author:KuhnVolkerV,
pubmed-author:PatschJosef RJR,
pubmed-author:RitschAndreasA,
pubmed-author:RudlingMatsM,
pubmed-author:SchgoerWilfriedW,
pubmed-author:StanzlUrsulaU,
pubmed-author:StellaardFransF,
pubmed-author:TancevskiIvanI,
pubmed-author:WehingerAndreasA
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
938-44
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pubmed:dateRevised |
2011-4-6
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pubmed:meshHeading |
pubmed-meshheading:19106072-Animals,
pubmed-meshheading:19106072-Anticholesteremic Agents,
pubmed-meshheading:19106072-Antigens, CD36,
pubmed-meshheading:19106072-Aorta,
pubmed-meshheading:19106072-Atherosclerosis,
pubmed-meshheading:19106072-Cell Line,
pubmed-meshheading:19106072-Cholesterol, Dietary,
pubmed-meshheading:19106072-Diet,
pubmed-meshheading:19106072-Disease Models, Animal,
pubmed-meshheading:19106072-Humans,
pubmed-meshheading:19106072-Hyperlipidemias,
pubmed-meshheading:19106072-Lipid Metabolism,
pubmed-meshheading:19106072-Liver,
pubmed-meshheading:19106072-Male,
pubmed-meshheading:19106072-Malonates,
pubmed-meshheading:19106072-Phenyl Ethers,
pubmed-meshheading:19106072-Rabbits
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pubmed:year |
2009
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pubmed:articleTitle |
The thyromimetic T-0681 protects from atherosclerosis.
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pubmed:affiliation |
Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria. ivan.tancevski@i-med.ac.at
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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