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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-10-28
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pubmed:abstractText |
Ex vivo cardiac preservation was evaluated by measuring the catabolism of high-energy phosphate (ATP and creatine phosphate, CrP) using 31P-NMR spectroscopy. After cardioplegic arrest St. Thomas' Hospital cardioplegic solution (group A), and University of Wisconsin (UW) preservation solution (group B) were tested. The hearts were mounted in the 4.7 T horizontal bore magnet of the NMR spectrometer and were continuously perfused with the test solution under 25 cm H2O pressure for 6 h at 10 degrees C. Peak heights of the beta-phosphate of ATP and CrP were measured and expressed as percentages of the initial value. For both group A and group B. ATP declined less rapidly during preservation than CrP. In group A, ATP remained constant for 60 min while CrP decreased from the onset of preservation. After 6 h of preservation 28.3% of ATP and 24.5% of CrP remained (group A). On the other hand, in group B, levels of both ATP and CrP remained much more stable: CrP did not decrease during the first 3 h of preservation, while ATP started to decrease after 5 h. At the end of preservation 76.1% of ATP and 71.5% of CrP were still present. We conclude that UW solution is superior to St. Thomas' Hospital solution for the preservation of high-energy phosphates during 6 h cardiac preservation with continuous hypothermic low-flow perfusion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Allopurinol,
http://linkedlifedata.com/resource/pubmed/chemical/Bicarbonates,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Cardioplegic Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium,
http://linkedlifedata.com/resource/pubmed/chemical/Organ Preservation Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Raffinose,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/St. Thomas' Hospital cardioplegic...,
http://linkedlifedata.com/resource/pubmed/chemical/University of...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0934-0874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1910434-Adenosine,
pubmed-meshheading:1910434-Allopurinol,
pubmed-meshheading:1910434-Animals,
pubmed-meshheading:1910434-Bicarbonates,
pubmed-meshheading:1910434-Calcium Chloride,
pubmed-meshheading:1910434-Cardioplegic Solutions,
pubmed-meshheading:1910434-Cryopreservation,
pubmed-meshheading:1910434-Glutathione,
pubmed-meshheading:1910434-Heart,
pubmed-meshheading:1910434-Insulin,
pubmed-meshheading:1910434-Magnesium,
pubmed-meshheading:1910434-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1910434-Male,
pubmed-meshheading:1910434-Myocardium,
pubmed-meshheading:1910434-Organ Preservation,
pubmed-meshheading:1910434-Organ Preservation Solutions,
pubmed-meshheading:1910434-Perfusion,
pubmed-meshheading:1910434-Phosphates,
pubmed-meshheading:1910434-Potassium Chloride,
pubmed-meshheading:1910434-Raffinose,
pubmed-meshheading:1910434-Rats,
pubmed-meshheading:1910434-Rats, Inbred Strains,
pubmed-meshheading:1910434-Sodium Chloride,
pubmed-meshheading:1910434-Solutions
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pubmed:year |
1991
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pubmed:articleTitle |
31P-NMR study of cardiac preservation: St. Thomas' Hospital cardioplegic solution versus UW preservation solution.
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pubmed:affiliation |
K.U. Leuven, Division Cardiac Surgery, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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