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rdf:type |
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lifeskim:mentions |
umls-concept:C0005821,
umls-concept:C0005847,
umls-concept:C0040053,
umls-concept:C0340652,
umls-concept:C0597357,
umls-concept:C0677535,
umls-concept:C0871261,
umls-concept:C1152760,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2009-1-6
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pubmed:abstractText |
Platelets are believed to play an important role in atherogenesis and the vessel response to vascular injury. The P2Y(12) receptor (P2Y(12)) plays a central role in amplifying platelet aggregation, dense granule and alpha-granule secretion, P-selectin expression, microparticle formation, and procoagulant membrane changes, regardless of the activating stimulus. We hypothesized that P2Y(12) deficiency might reduce the vessel wall response to vascular injury as well as thrombosis in murine vascular injury models.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Ferric Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Noxae,
http://linkedlifedata.com/resource/pubmed/chemical/P-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/P2ry12 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y12,
http://linkedlifedata.com/resource/pubmed/chemical/ferric chloride
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
6
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-22
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19103996-Animals,
pubmed-meshheading:19103996-Atherosclerosis,
pubmed-meshheading:19103996-Blood Platelets,
pubmed-meshheading:19103996-Bone Marrow Transplantation,
pubmed-meshheading:19103996-Chlorides,
pubmed-meshheading:19103996-Disease Models, Animal,
pubmed-meshheading:19103996-Female,
pubmed-meshheading:19103996-Femoral Artery,
pubmed-meshheading:19103996-Ferric Compounds,
pubmed-meshheading:19103996-Male,
pubmed-meshheading:19103996-Mice,
pubmed-meshheading:19103996-Mice, Inbred C57BL,
pubmed-meshheading:19103996-Mice, Mutant Strains,
pubmed-meshheading:19103996-Muscle, Smooth, Vascular,
pubmed-meshheading:19103996-Noxae,
pubmed-meshheading:19103996-P-Selectin,
pubmed-meshheading:19103996-Platelet Aggregation,
pubmed-meshheading:19103996-Receptors, Purinergic P2,
pubmed-meshheading:19103996-Receptors, Purinergic P2Y12,
pubmed-meshheading:19103996-Thrombosis,
pubmed-meshheading:19103996-Tunica Intima
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pubmed:year |
2009
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pubmed:articleTitle |
Platelet P2Y(12) receptor influences the vessel wall response to arterial injury and thrombosis.
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pubmed:affiliation |
Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, Sheffield, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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