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rdf:type |
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lifeskim:mentions |
umls-concept:C0005437,
umls-concept:C0006556,
umls-concept:C0009015,
umls-concept:C0015576,
umls-concept:C0017262,
umls-concept:C0023884,
umls-concept:C0070570,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205360,
umls-concept:C0680022,
umls-concept:C2911684
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pubmed:dateCreated |
1991-10-21
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pubmed:abstractText |
A new human liver UDP-glucuronosyltransferase (HlugP4) has been cloned and expressed in cell culture. The expressed enzyme has a molecular mass of 56 kDa and preferentially catalysed the glucuronidation of halogenated and bulky alkyl phenols. The C-terminal half of the sequence (246 amino acids) is 96% identical with the same portion of HlugP1, whereas the N-terminal half of the deduced protein sequences are only 38% identical. These results suggest that the two isoenzymes may be derived from the same gene by differential splicing of the gene product.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-1697681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-1847492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-1898728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-1900159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2105949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2108603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2112380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2116769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2117826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2125483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2148485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2445560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2492950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2506584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-2988123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3096993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3100939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3109396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3110589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3124857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3141926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3143063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3143908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-3313277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-6320016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1910331-6329026
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
278 ( Pt 2)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
465-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1910331-Amino Acid Sequence,
pubmed-meshheading:1910331-Base Sequence,
pubmed-meshheading:1910331-Blotting, Western,
pubmed-meshheading:1910331-Cell Line,
pubmed-meshheading:1910331-Cloning, Molecular,
pubmed-meshheading:1910331-DNA,
pubmed-meshheading:1910331-Glucuronosyltransferase,
pubmed-meshheading:1910331-Humans,
pubmed-meshheading:1910331-Isoenzymes,
pubmed-meshheading:1910331-Liver,
pubmed-meshheading:1910331-Microsomes,
pubmed-meshheading:1910331-Molecular Sequence Data,
pubmed-meshheading:1910331-Multigene Family
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pubmed:year |
1991
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pubmed:articleTitle |
Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family.
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pubmed:affiliation |
Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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