Source:http://linkedlifedata.com/resource/pubmed/id/19103258
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2009-1-19
|
| pubmed:abstractText |
Pain is associated with swallowing abnormalities in dysphagic patients. Understanding neuronal mechanisms underlying the swallowing abnormalities associated with orofacial abnormal pain is crucial for developing new methods to treat dysphagic patients. However, how the orofacial abnormal pain is involved in the swallowing abnormalities is not known. In order to evaluate neuronal mechanisms of modulation of the swallows by masticatory muscle pain, here we first induced swallows by topical administration of distilled water to the pharyngolaryngeal region. The swallowing reflex was significantly inhibited after capsaicin (10, 30mM) injection into the masseter muscle compared to vehicle injection. Moreover the number of phosphorylated extracellular signal-regulated kinase-like immunoreactive (pERK-LI) neurons in the nucleus tractus solitarii (NTS) was significantly increased in the rats with capsaicin injection into the masseter muscle compared to that with vehicle injection. Rostro-caudal distribution of pERK-LI neurons in the NTS was peaked at the obex level. The capsaicin-induced inhibitory effect on swallowing reflex was reversed after intrathecal administration of mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor, PD98059. The present findings suggest that phosphorylation of ERK in NTS neurons may be involved in capsaicin-induced inhibition of swallowing reflex.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
6
|
| pubmed:volume |
450
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
361-4
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:19103258-Animals,
pubmed-meshheading:19103258-Capsaicin,
pubmed-meshheading:19103258-Deglutition,
pubmed-meshheading:19103258-Deglutition Disorders,
pubmed-meshheading:19103258-Enzyme Inhibitors,
pubmed-meshheading:19103258-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:19103258-Male,
pubmed-meshheading:19103258-Masseter Muscle,
pubmed-meshheading:19103258-Mastication,
pubmed-meshheading:19103258-Neural Inhibition,
pubmed-meshheading:19103258-Neural Pathways,
pubmed-meshheading:19103258-Neurons,
pubmed-meshheading:19103258-Nociceptors,
pubmed-meshheading:19103258-Pain,
pubmed-meshheading:19103258-Phosphorylation,
pubmed-meshheading:19103258-Rats,
pubmed-meshheading:19103258-Rats, Sprague-Dawley,
pubmed-meshheading:19103258-Reflex,
pubmed-meshheading:19103258-Solitary Nucleus,
pubmed-meshheading:19103258-Up-Regulation
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Inhibition of swallowing reflex following phosphorylation of extracellular signal-regulated kinase in nucleus tractus solitarii neurons in rats with masseter muscle nociception.
|
| pubmed:affiliation |
Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, 1-8-13 Kandasurugadai, Chiyoda-ku, Tokyo 101-8310, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|