Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-8
pubmed:abstractText
Macrocyclic bis-lactams have been synthesized by cyclodimerization of homoallylic amino esters employing a Zr(IV)-catalyzed ester-amide exchange protocol. Base-mediated transannular cyclizations have been identified to access both bicyclic [5-11] and tricyclic [5-8-5] frameworks in good yield and diastereoselectivity. Preliminary mechanistic studies support an olefin isomerization-intramolecular conjugate addition pathway.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-11405667, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-12790551, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-15002980, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-15939326, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-16011366, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-16153061, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-16209514, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-16562872, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-16774237, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-16774273, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-17105291, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-17105295, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-17263426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-17602636, http://linkedlifedata.com/resource/pubmed/commentcorrection/19102683-17994738
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1523-7052
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
413-6
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams.
pubmed:affiliation
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural