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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-27
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pubmed:abstractText |
The optimization of imidazo[1,2-a]pyridine inhibitors as potent and selective inhibitors of IGF-1R is presented. Further optimization of oral exposure in mice is also discussed. Detailed selectivity, in vitro activity, and in vivo PK profiles of an optimized compound is also highlighted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AndersonKellyK,
pubmed-author:AtkinsCharity LCL,
pubmed-author:BaumErich WEW,
pubmed-author:CheungMuiM,
pubmed-author:DickersonScott HSH,
pubmed-author:EmersonHolly KHK,
pubmed-author:EmmitteKyle AKA,
pubmed-author:GerdingRoseanne MRM,
pubmed-author:GroyArthurA,
pubmed-author:HassellAnne MAM,
pubmed-author:KumarRakeshR,
pubmed-author:KuntzKevin WKW,
pubmed-author:LeesnitzerM AnthonyMA,
pubmed-author:MookRobert ARAJr,
pubmed-author:MoorthyGanesh SGS,
pubmed-author:NailorKristen EKE,
pubmed-author:RowandJason LJL,
pubmed-author:SabbatiniPeterP,
pubmed-author:SalovichJames MJM,
pubmed-author:ShewchukLisa MLM,
pubmed-author:SmithStephon CSC,
pubmed-author:StevensKirk LKL,
pubmed-author:UehlingDavid EDE,
pubmed-author:WilsonBrian JBJ,
pubmed-author:YangJingsongJ
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1004-8
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pubmed:meshHeading |
pubmed-meshheading:19101143-Administration, Oral,
pubmed-meshheading:19101143-Aniline Compounds,
pubmed-meshheading:19101143-Animals,
pubmed-meshheading:19101143-Cell Line, Tumor,
pubmed-meshheading:19101143-Chemistry, Pharmaceutical,
pubmed-meshheading:19101143-Crystallography, X-Ray,
pubmed-meshheading:19101143-Drug Design,
pubmed-meshheading:19101143-Humans,
pubmed-meshheading:19101143-Inhibitory Concentration 50,
pubmed-meshheading:19101143-Mice,
pubmed-meshheading:19101143-Models, Chemical,
pubmed-meshheading:19101143-Molecular Conformation,
pubmed-meshheading:19101143-Pyridines,
pubmed-meshheading:19101143-Receptor, IGF Type 1,
pubmed-meshheading:19101143-Receptor, Insulin
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pubmed:year |
2009
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pubmed:articleTitle |
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
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pubmed:affiliation |
GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. kyle.a.emmitte@Vanderbilt.edu
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pubmed:publicationType |
Journal Article
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