Source:http://linkedlifedata.com/resource/pubmed/id/19099482
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2009-1-12
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pubmed:abstractText |
This study was designed to determine whether the functional IL-10 gene polymorphism -1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients' cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by left-ventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
451-4
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pubmed:meshHeading |
pubmed-meshheading:19099482-Adult,
pubmed-meshheading:19099482-Aged,
pubmed-meshheading:19099482-Chagas Cardiomyopathy,
pubmed-meshheading:19099482-Cross-Sectional Studies,
pubmed-meshheading:19099482-Female,
pubmed-meshheading:19099482-Gene Expression Regulation,
pubmed-meshheading:19099482-Genetic Predisposition to Disease,
pubmed-meshheading:19099482-Genotype,
pubmed-meshheading:19099482-Humans,
pubmed-meshheading:19099482-Interleukin-10,
pubmed-meshheading:19099482-Male,
pubmed-meshheading:19099482-Middle Aged,
pubmed-meshheading:19099482-Polymorphism, Genetic,
pubmed-meshheading:19099482-Risk Factors,
pubmed-meshheading:19099482-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy.
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pubmed:affiliation |
Laboratory of Cell-Cell Interactions, Department of Morphology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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