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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-22
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pubmed:abstractText |
Concise total synthesis of obovatol (1) was achieved from the commercially available eugenol (5) via linear 4 steps in 40% overall yield. The key features of the synthesis involve the chemoselective orthobromination of phenol in the presence of isolated double bond and the efficient Cu-catalyzed Ullmann coupling of two aromatic moieties for the diaryl ether skeleton.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0253-6269
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pubmed:author |
pubmed-author:ChoiEun-HwaEH,
pubmed-author:HongJin TaeJT,
pubmed-author:InJin-KyungJK,
pubmed-author:JungJae-KyungJK,
pubmed-author:KwakJae-HwanJH,
pubmed-author:LeeHeesoonH,
pubmed-author:LeeMi-SungMS,
pubmed-author:LeeSoo JaeSJ,
pubmed-author:SeoSeung-YongSY,
pubmed-author:SuhYoung-GerYG,
pubmed-author:YunYeo-PyoYP
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1559-63
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pubmed:meshHeading |
pubmed-meshheading:19099224-Alkenes,
pubmed-meshheading:19099224-Anti-Infective Agents,
pubmed-meshheading:19099224-Biphenyl Compounds,
pubmed-meshheading:19099224-Bromine,
pubmed-meshheading:19099224-Catalysis,
pubmed-meshheading:19099224-Copper,
pubmed-meshheading:19099224-Ethers,
pubmed-meshheading:19099224-Ligands,
pubmed-meshheading:19099224-Phenols,
pubmed-meshheading:19099224-Phenyl Ethers,
pubmed-meshheading:19099224-Spectrophotometry, Infrared,
pubmed-meshheading:19099224-Spectroscopy, Fourier Transform Infrared
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pubmed:year |
2008
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pubmed:articleTitle |
Concise synthesis of Obovatol: Chemoselective ortho-bromination of phenol and survey of Cu-catalyzed diaryl ether couplings.
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pubmed:affiliation |
College of Pharmacy, CBITRC, Chungbuk National University, Cheongju, 361-763, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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