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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-27
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pubmed:abstractText |
Based on the structural similarity between the naturally occurring cyclic heptapeptides rhizonin A and ternatin, two novel analogues were designed. The synthetic analogues were assessed with regard to their fat-accumulation inhibitory effect against 3T3-L1 adipocytes, and this led to the discovery of a potent and selective fat-accumulation inhibitor compared to the parent compound rhizonin A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
867-9
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pubmed:meshHeading |
pubmed-meshheading:19097891-3T3-L1 Cells,
pubmed-meshheading:19097891-Adipocytes,
pubmed-meshheading:19097891-Animals,
pubmed-meshheading:19097891-Chemistry, Pharmaceutical,
pubmed-meshheading:19097891-Drug Design,
pubmed-meshheading:19097891-Flavonoids,
pubmed-meshheading:19097891-Inhibitory Concentration 50,
pubmed-meshheading:19097891-Mice,
pubmed-meshheading:19097891-Models, Biological,
pubmed-meshheading:19097891-Models, Chemical,
pubmed-meshheading:19097891-Molecular Conformation,
pubmed-meshheading:19097891-Nucleic Acid Hybridization,
pubmed-meshheading:19097891-Peptides,
pubmed-meshheading:19097891-Peptides, Cyclic
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pubmed:year |
2009
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pubmed:articleTitle |
Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes.
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pubmed:affiliation |
Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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