Linked Life Data

1909705

Source:http://linkedlifedata.com/resource/pubmed/id/1909705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-10-17
pubmed:abstractText
Serum steroid, gonadotropin, and alpha-subunit levels were assessed in 35 women with cycle abnormalities [11 with and 24 without polycystic ovarian disease (PCOD) according to strict clinical and biochemical criteria] and 8 regularly cycling women in the early (cycle day 3 or 4) and mid (cycle day 7 or 8) follicular phase. LH and FSH levels were estimated using two immunological techniques [RIA and immunoradiometric assay (IRMA)] and in vitro bioassays (BIO), using mouse Leydig cells and rat granulosa cells, respectively. In PCOD patients mean alpha-subunit, free androgen index [FAI; testosterone x 100/sex hormone-binding globulin (SHBG)], androstenedione, estrone, and estradiol (E2) were significantly elevated compared to levels in the early follicular phase of control cycles and non-PCOD patients. In addition, in PCOD patients mean IRMA-LH and RIA-LH levels were distinctly increased (2.8- to 3.6 fold, respectively; both comparisons, P less than 0.001) compared to control values, but in the same order of magnitude (1.3- to 1.4-fold increments) as that in non-PCOD patients. However, the median BIO-LH level in PCOD patients was 5.9-fold higher than that in non-PCOD patients and 4.0-fold higher than the BIO-LH in the early follicular phase of control women. Consequently, the median BIO/IRMA-LH ratio was 4.8-fold higher in PCOD patients compared to non-PCOD patients. In women with cycle abnormalities, individual BIO/IRMA-LH ratios correlated with BIO-LH (rs = 0.48), FAI (rs = 0.39), free estrogens (E2/SHBG ratios; rs = 0 0.47), and dehydroepiandrosterone sulfate (rs = 0.60) concentrations. Mean IRMA-, RIA-, and BIO-FSH levels and BIO/IRMA-FSH ratios were not significantly different when various groups were compared. Although RIA- and IRMA-LH levels showed good correlation (rs = 0.88), RIA-LH levels were consistently higher, resulting in distinctly higher RIA-LH/FSH ratios (mean, 4.5) compared to IRMA-LH/FSH ratios (median, 1.8) in PCOD patients.(ABSTRACT TRUNCATED AT 400 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
811-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1909705-Adult, pubmed-meshheading:1909705-Androgens, pubmed-meshheading:1909705-Androstenedione, pubmed-meshheading:1909705-Animals, pubmed-meshheading:1909705-Cells, Cultured, pubmed-meshheading:1909705-Estradiol, pubmed-meshheading:1909705-Estrone, pubmed-meshheading:1909705-Female, pubmed-meshheading:1909705-Follicle Stimulating Hormone, pubmed-meshheading:1909705-Granulosa Cells, pubmed-meshheading:1909705-Humans, pubmed-meshheading:1909705-Immunoradiometric Assay, pubmed-meshheading:1909705-Leydig Cells, pubmed-meshheading:1909705-Luteinizing Hormone, pubmed-meshheading:1909705-Male, pubmed-meshheading:1909705-Menstrual Cycle, pubmed-meshheading:1909705-Menstruation Disturbances, pubmed-meshheading:1909705-Mice, pubmed-meshheading:1909705-Polycystic Ovary Syndrome, pubmed-meshheading:1909705-Radioimmunoassay, pubmed-meshheading:1909705-Rats, pubmed-meshheading:1909705-Sex Hormone-Binding Globulin, pubmed-meshheading:1909705-Testosterone
pubmed:year
1991
pubmed:articleTitle
Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in women with cycle abnormalities, with or without polycystic ovarian disease.
pubmed:affiliation
Department of Obstetrics and Gynecology, Dijkzigt University Hospital, Rotterdam, The Netherlands.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't