Linked Life Data

1909701

Source:http://linkedlifedata.com/resource/pubmed/id/1909701

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-10-17
pubmed:abstractText
To assess further the relationship between gonadal sex steroids and PRL, GH, and insulin-like growth factor-I (IGF-I) secretion and to help clarify the mechanism underlying the pubertal growth spurt, we studied 11 children (10 girls) with central precocious puberty before and during gonadal suppression with the GnRH agonist (GnRH-a) leuprolide acetate. Nocturnal sampling for plasma levels of GH and PRL, GH response to GH-releasing factor-(1-44), and plasma IGF-I levels were determined before and 3-6 months after pituitary-gonadal suppression. Treatment caused a significant decrease in the LH and FSH responses to GnRH (P less than 0.01) and the plasma concentration of estradiol (P less than 0.05). The patients' mean height velocity SD score for chronological age, initially 3.8 +/- 1.9, decreased significantly to 0.9 +/- 0.9 with treatment (P less than 0.005). Nocturnal GH secretion (mean GH concentration, sum of GH pulse areas, sum of GH pulse amplitudes, and GH pulse frequency) and mean IGF-I levels (1.38 +/- 0.6 vs. 1.72 +/- 0.34 U/mL) were not significantly altered by treatment. However, the mean peak GH response to GH-releasing factor-(1-44) was 29.2 +/- 6.8 micrograms/L before treatment and declined significantly to 17.7 +/- 3.4 micrograms/L after gonadal suppression (P less than 0.05). PRL secretion was similar before and after GnRH-a-induced suppression. These results indicate that the decrease in height velocity noted during GnRH-a treatment occurred independently of changes in nocturnal GH secretion and IGF-I levels. These data are consistent with the premise that sex steroids can modulate growth by a direct action on skeletal growth.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
734-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1909701-Antineoplastic Agents, pubmed-meshheading:1909701-Body Height, pubmed-meshheading:1909701-Child, pubmed-meshheading:1909701-Child, Preschool, pubmed-meshheading:1909701-Estradiol, pubmed-meshheading:1909701-Female, pubmed-meshheading:1909701-Follicle Stimulating Hormone, pubmed-meshheading:1909701-Gonadotropin-Releasing Hormone, pubmed-meshheading:1909701-Gonads, pubmed-meshheading:1909701-Growth, pubmed-meshheading:1909701-Growth Hormone, pubmed-meshheading:1909701-Humans, pubmed-meshheading:1909701-Insulin-Like Growth Factor I, pubmed-meshheading:1909701-Leuprolide, pubmed-meshheading:1909701-Luteinizing Hormone, pubmed-meshheading:1909701-Male, pubmed-meshheading:1909701-Pituitary Gland, pubmed-meshheading:1909701-Prolactin, pubmed-meshheading:1909701-Puberty, Precocious
pubmed:year
1991
pubmed:articleTitle
Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion.
pubmed:affiliation
Department of Pediatrics, New York University Medical Center, New York 10016.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S.