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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1991-10-16
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pubmed:abstractText |
Cepharanthine, isolated from Stephania cepharantha, is one of the bisbenzylisoquinoline-type alkaloids. We have found that it inhibits tumor promotion after topical application in two-stage carcinogenesis in mouse skin. Epidermal ornithine decarboxylase activities inhibited by topical application of cepharanthine, with an 5 micrograms/mouse) and mezerein (5 micrograms/mouse) were found to be inhibited by topical application of cepharanthine, with a ED50 of 1.2 mumol and 1.4 mumol respectively. These inhibitory effects of cepharanthine are considered to be related to its antitumor activity in two-stage carcinogenesis in mouse skin. Cell-mediated immunosuppression by TPA was unaffected by topical application of cepharanthine. A diet containing 0.005% cepharanthine (about 0.5 mg mouse-1 day-1) slightly suppressed the two-stage promotion of skin tumors by twice-weekly applications of 2.5 micrograms TPA for 2 weeks (first stage) followed by twice-weekly applications of 2.5 micrograms mezerein for 23 weeks (second stage) in ICR mice following initiation by 50 micrograms 7,12-dimethylbenz[a]anthracene. Oral administration of cepharanthine inhibits the tumor promotion in two-stage carcinogenesis in mouse skin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/9,10-Dimethyl-1,2-benzanthracene,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Ornithine Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/cepharanthine,
http://linkedlifedata.com/resource/pubmed/chemical/mezerein
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pubmed:status |
MEDLINE
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1909698-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:1909698-Administration, Oral,
pubmed-meshheading:1909698-Administration, Topical,
pubmed-meshheading:1909698-Alkaloids,
pubmed-meshheading:1909698-Animals,
pubmed-meshheading:1909698-Benzylisoquinolines,
pubmed-meshheading:1909698-Carcinogens,
pubmed-meshheading:1909698-Diterpenes,
pubmed-meshheading:1909698-Drug Interactions,
pubmed-meshheading:1909698-Enzyme Induction,
pubmed-meshheading:1909698-Female,
pubmed-meshheading:1909698-Immunity, Cellular,
pubmed-meshheading:1909698-Mice,
pubmed-meshheading:1909698-Mice, Inbred ICR,
pubmed-meshheading:1909698-Ornithine Decarboxylase,
pubmed-meshheading:1909698-Skin,
pubmed-meshheading:1909698-Skin Neoplasms,
pubmed-meshheading:1909698-Terpenes,
pubmed-meshheading:1909698-Tetradecanoylphorbol Acetate
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pubmed:year |
1991
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pubmed:articleTitle |
Cepharanthine inhibits two-stage tumor promotion by 12-O-tetradecanoylphorbol 13-acetate and mezerein on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
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pubmed:affiliation |
College of Pharmacy, Nihon University, Chiba, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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