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rdf:type |
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lifeskim:mentions |
umls-concept:C0017256,
umls-concept:C0025646,
umls-concept:C0026882,
umls-concept:C0205225,
umls-concept:C0242379,
umls-concept:C1417123,
umls-concept:C1514562,
umls-concept:C1521996,
umls-concept:C1622525,
umls-concept:C1879547,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-19
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pubmed:abstractText |
MET (Met proto-oncogene) activation either by gene amplification or mutation is implicated in various types of human cancers. For lung cancer, MET gene amplification is reported to occur in a subset of adenocarcinomas. Although somatic mutations of MET in lung adenocarcinomas are rare, all but one of those reported so far entail a splice mutation deleting the juxtamembrane domain for binding the c-Cbl E3-ligase; normally such binding leads to ubiquitination and receptor degradation, and loss of this domain leads to MET activation. The purpose of this study was to clarify in the role of MET activation in lung carcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/EGFR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ERBB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MET protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-cbl,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin-Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1556-1380
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-11
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19096300-Adenocarcinoma,
pubmed-meshheading:19096300-Adult,
pubmed-meshheading:19096300-Aged,
pubmed-meshheading:19096300-Aged, 80 and over,
pubmed-meshheading:19096300-Alternative Splicing,
pubmed-meshheading:19096300-Base Sequence,
pubmed-meshheading:19096300-Carcinoma, Adenosquamous,
pubmed-meshheading:19096300-Carcinoma, Large Cell,
pubmed-meshheading:19096300-Carcinoma, Squamous Cell,
pubmed-meshheading:19096300-Female,
pubmed-meshheading:19096300-Gene Amplification,
pubmed-meshheading:19096300-Gene Dosage,
pubmed-meshheading:19096300-Humans,
pubmed-meshheading:19096300-Lung Neoplasms,
pubmed-meshheading:19096300-Male,
pubmed-meshheading:19096300-Middle Aged,
pubmed-meshheading:19096300-Molecular Sequence Data,
pubmed-meshheading:19096300-Mutation,
pubmed-meshheading:19096300-Neoplasm Staging,
pubmed-meshheading:19096300-Pneumonectomy,
pubmed-meshheading:19096300-Prognosis,
pubmed-meshheading:19096300-Protein Structure, Tertiary,
pubmed-meshheading:19096300-Proto-Oncogene Proteins,
pubmed-meshheading:19096300-Proto-Oncogene Proteins c-cbl,
pubmed-meshheading:19096300-Proto-Oncogene Proteins c-met,
pubmed-meshheading:19096300-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19096300-Receptor, erbB-2,
pubmed-meshheading:19096300-Receptors, Growth Factor,
pubmed-meshheading:19096300-Sequence Deletion,
pubmed-meshheading:19096300-Small Cell Lung Carcinoma,
pubmed-meshheading:19096300-Tumor Cells, Cultured,
pubmed-meshheading:19096300-Ubiquitin-Protein Ligases,
pubmed-meshheading:19096300-ras Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers.
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pubmed:affiliation |
Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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