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rdf:type |
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lifeskim:mentions |
umls-concept:C0004153,
umls-concept:C0007634,
umls-concept:C0023516,
umls-concept:C0054874,
umls-concept:C0205179,
umls-concept:C0243127,
umls-concept:C0331858,
umls-concept:C0443331,
umls-concept:C1704640,
umls-concept:C1704735,
umls-concept:C1706515
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-23
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pubmed:abstractText |
A dysbalance of proteases and their inhibitors is instrumental in remodeling of atherosclerotic plaques. One of the proteases implicated in matrix degradation is cathepsin-S (CatS). To address its role in advanced lesion composition, we generated chimeric LDLr(-/-) mice deficient in leukocyte CatS by transplantation with CatS(-/-)xLDLr(-/-) or with LDLr(-/-) bone marrow and administered a high-fat diet.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:BiessenE A LEA,
pubmed-author:BosHH,
pubmed-author:DorlandRR,
pubmed-author:JukemaJ WJW,
pubmed-author:KovanenP TPT,
pubmed-author:KraaijeveldA OAO,
pubmed-author:LeeuwenburghM AMA,
pubmed-author:OverkleeftH SHS,
pubmed-author:ShiG PGP,
pubmed-author:WestraM MMM,
pubmed-author:de NooijerRR,
pubmed-author:van BerkelTh J CTJ,
pubmed-author:van HeiningenS HSH,
pubmed-author:van SantbrinkP JPJ,
pubmed-author:van der WallE EEE,
pubmed-author:von der ThüsenJ HJH
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188-94
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pubmed:meshHeading |
pubmed-meshheading:19095996-Animals,
pubmed-meshheading:19095996-Aorta,
pubmed-meshheading:19095996-Apoptosis,
pubmed-meshheading:19095996-Atherosclerosis,
pubmed-meshheading:19095996-Bone Marrow Transplantation,
pubmed-meshheading:19095996-Cathepsins,
pubmed-meshheading:19095996-Cell Movement,
pubmed-meshheading:19095996-Cell Proliferation,
pubmed-meshheading:19095996-Cells, Cultured,
pubmed-meshheading:19095996-Cholesterol,
pubmed-meshheading:19095996-Collagen,
pubmed-meshheading:19095996-Diet, Atherogenic,
pubmed-meshheading:19095996-Disease Models, Animal,
pubmed-meshheading:19095996-Elastic Tissue,
pubmed-meshheading:19095996-Extracellular Matrix,
pubmed-meshheading:19095996-Female,
pubmed-meshheading:19095996-Foam Cells,
pubmed-meshheading:19095996-Leukocytes,
pubmed-meshheading:19095996-Macrophages, Peritoneal,
pubmed-meshheading:19095996-Mice,
pubmed-meshheading:19095996-Mice, Knockout,
pubmed-meshheading:19095996-Myocytes, Smooth Muscle,
pubmed-meshheading:19095996-Necrosis,
pubmed-meshheading:19095996-Protease Inhibitors,
pubmed-meshheading:19095996-Receptors, LDL,
pubmed-meshheading:19095996-Transplantation Chimera
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pubmed:year |
2009
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pubmed:articleTitle |
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis.
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pubmed:affiliation |
Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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