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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
52
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pubmed:dateCreated |
2008-12-31
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pubmed:abstractText |
Specific pathogen-free IL-10 KO mice failed to develop inflammatory bowel disease (IBD), whereas IL-10/vitamin D receptor (VDR) double KO mice developed fulminating IBD. WT CD4 T cells inhibited experimental IBD, while VDR KO CD4 T cells failed to suppress IBD. VDR KO mice had normal numbers and functions of regulatory T cells. The percentages of IL-17- and IFN-gamma-secreting T cells in the gut of mice reconstituted with WT and VDR KO CD4 T cells were also not different. Instead, there were twice as many CD8alphaalpha intraepithelial lymphocytes (IEL) in mice that were reconstituted with WT CD4 T cells than in mice reconstituted with VDR KO CD4 T cells. Furthermore, VDR KO mice had reduced numbers of CD8alphaalpha IEL, absent CD4/CD8alphaalpha populations, and as a result low IL-10 production in the IEL. The lack of CD8alphaalpha IEL was due in part to decreased CCR9 expression on T cells that resulted in the failure of the VDR KO T cells to home to the small intestine. We conclude that the VDR mediates T cell homing to the gut and as a result the VDR KO mouse has reduced numbers of CD8alphaalpha IEL with low levels of IL-10 leading to increased inflammatory response to the normally harmless commensal flora.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-10896912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-11053501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-11726533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-11877483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-11978632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-12695566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-12874827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-12876555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-14500760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-14633949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-15032579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-15564440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-15684874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-16670770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-17030948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-17259988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-17397543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-18275828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-18566595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-8394753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19095793-8691138
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/CC chemokine receptor 9,
http://linkedlifedata.com/resource/pubmed/chemical/CD8 antigen, alpha chain,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitriol
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20834-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19095793-Animals,
pubmed-meshheading:19095793-Antigens, CD4,
pubmed-meshheading:19095793-Antigens, CD8,
pubmed-meshheading:19095793-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19095793-Inflammatory Bowel Diseases,
pubmed-meshheading:19095793-Intestinal Mucosa,
pubmed-meshheading:19095793-Mice,
pubmed-meshheading:19095793-Mice, Knockout,
pubmed-meshheading:19095793-Receptors, CCR,
pubmed-meshheading:19095793-Receptors, Calcitriol
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pubmed:year |
2008
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pubmed:articleTitle |
Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice.
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pubmed:affiliation |
Center for Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, Pennsylvania State University, University Park, PA 16802, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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