Linked Life Data

19091579

Source:http://linkedlifedata.com/resource/pubmed/id/19091579

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Nineteen ursolic acid derivatives (15 novel compounds) modified at the C-3 and the C-28 positions were synthesized. The cytotoxic activity of the derivatives was evaluated against HeLa, BGC-823 and SKOV3 cells by MTT assay. Inducing apoptosis and affecting cell cycle distribution by the derivatives in HeLa cells were assessed by flow cytometry and DNA fragmentation. Compounds 10b and 11b were particularly active to inhibit HeLa cells growth through inducing apoptosis and arresting cell cycle progression. The typical 'sub-G1 peak' and DNA ladder formation were checked and cell cycle was arrested at the S phase in a dose-dependent manner.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1464-3391
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
848-54
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action.
pubmed:affiliation
Department of Pharmaceutical Engineering, Shenyang Institute of Chemical Technology, Jing Ji Kai Fa Que 11 street, Shenyang 110142, PR China. mengyanqiu@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't