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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-12-26
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pubmed:abstractText |
The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
305-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19091560-Cell Line, Tumor,
pubmed-meshheading:19091560-Cyclin D1,
pubmed-meshheading:19091560-Cyclin-Dependent Kinase 4,
pubmed-meshheading:19091560-Drug Screening Assays, Antitumor,
pubmed-meshheading:19091560-Humans,
pubmed-meshheading:19091560-Hydrazones,
pubmed-meshheading:19091560-Protein Kinase Inhibitors,
pubmed-meshheading:19091560-Pyrimidines,
pubmed-meshheading:19091560-Structure-Activity Relationship
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pubmed:year |
2009
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pubmed:articleTitle |
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.
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pubmed:affiliation |
Medicinal Chemistry Research Laboratory II, Daiichi Sankyo Co. Ltd., 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. horiuchi.takao.pi@daiichisankyo.co.jp
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pubmed:publicationType |
Journal Article
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