Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-12-25
pubmed:abstractText
It was recently reported that the production of Reactive Oxygen Species (ROS) is a common mechanism of cell death induced by bactericidal antibiotics. Here we show that triggering the Escherichia coli chromosomal toxin-antitoxin system mazEF is an additional determinant in the mode of action of some antibiotics. We treated E. coli cultures by antibiotics belonging to one of two groups: (i) Inhibitors of transcription and/or translation, and (ii) DNA damaging. We found that antibiotics of both groups caused: (i) mazEF-mediated cell death, and (ii) the production of ROS through MazF action. However, only antibiotics of the first group caused mazEF-mediated cell death that is ROS-dependent, whereas those of the second group caused mazEF-mediated cell death by an ROS-independent pathway. Furthermore, our results showed that the mode of action of antibiotics was determined by the ability of E. coli cells to communicate through the signaling molecule Extracellular Death Factor (EDF) participating in mazEF induction.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-10811907, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-10908675, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-10943559, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-10963607, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-11222603, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-11579426, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-12172961, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-12618443, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-12970556, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-12972253, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-14580342, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-14970189, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-14999632, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-15150257, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-15308657, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-15537630, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-15576778, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-16482223, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-16621839, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-1695893, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-1696718, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-17803904, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-17962566, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-18310334, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-2563380, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-2834821, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-2870062, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-2988786, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-6348554, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-8650219, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-9293187, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-9304210, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-9523706, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-9808629, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-9860994, http://linkedlifedata.com/resource/pubmed/commentcorrection/19090622-9891809
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents, http://linkedlifedata.com/resource/pubmed/chemical/Catalase, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Endoribonucleases, http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins, http://linkedlifedata.com/resource/pubmed/chemical/MazE protein, E coli, http://linkedlifedata.com/resource/pubmed/chemical/MazF protein, E coli, http://linkedlifedata.com/resource/pubmed/chemical/Nalidixic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides, http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species, http://linkedlifedata.com/resource/pubmed/chemical/Rifampin, http://linkedlifedata.com/resource/pubmed/chemical/asparagyl-aspargyl-tryptophyl-aspara...
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1545-7885
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e319
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibiotics.
pubmed:affiliation
Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural