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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-10-3
|
| pubmed:abstractText |
The effect of a high dietary intake of n-6 fatty acids (36 g daily) vs a low intake (4-6 g daily) on the incorporation of fatty acids from a dietary supplementation of n-3 fatty acids (6 g daily) was studied for 8 weeks in 15 healthy, normolipaemic volunteers. The importance of a high (43.6) vs a low (20.6) energy percentage from fat was also investigated in the participants on a low n-6 intake. Fatty acid analyses of serum and thrombocyte phospholipids showed a marked increase in docosahexaenoic acid (22:6 (n-3), DHA) and especially eicosapentaenoic acid (20:5 (n-3), EPA) in both the high and low n-6 groups after 14 days, but the changes were significantly greater in the low n-6 diet groups. Changes of the ratio between EPA and arachidonic acid (20:4 (n-6), AA) in phospholipids followed an identical pattern in serum and thrombocytes. This indicates that thrombocytes are influenced by the fatty acid composition in serum. The results showed that incorporation of n-3 fatty acids in phospholipids was reduced by a high intake of dietary n-6 fatty acids in the cells and lipid fractions studied. The observed effect of dietary n-6 fatty acids was independent of the energy percentage provided by dietary fat. In order to obtain an optimal effect of n-3 supplementation, the intake of linoleic acid has to be considered and kept at a low level. The serum content of cholesterol was unaffected, but the concentration of triacylglycerol was reduced during the supplementation period.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosapentaenoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-6,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0036-5513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
255-63
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1909049-Adult,
pubmed-meshheading:1909049-Arachidonic Acid,
pubmed-meshheading:1909049-Arachidonic Acids,
pubmed-meshheading:1909049-Blood Platelets,
pubmed-meshheading:1909049-Cholesterol,
pubmed-meshheading:1909049-Chromatography, Gas,
pubmed-meshheading:1909049-Eicosapentaenoic Acid,
pubmed-meshheading:1909049-Fatty Acids, Omega-3,
pubmed-meshheading:1909049-Fatty Acids, Omega-6,
pubmed-meshheading:1909049-Fatty Acids, Unsaturated,
pubmed-meshheading:1909049-Female,
pubmed-meshheading:1909049-Humans,
pubmed-meshheading:1909049-Linoleic Acid,
pubmed-meshheading:1909049-Linoleic Acids,
pubmed-meshheading:1909049-Male,
pubmed-meshheading:1909049-Middle Aged,
pubmed-meshheading:1909049-Phospholipids,
pubmed-meshheading:1909049-Prospective Studies,
pubmed-meshheading:1909049-Triglycerides
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Dietary n-6 fatty acids inhibit the incorporation of dietary n-3 fatty acids in thrombocyte and serum phospholipids in humans: a controlled dietetic study.
|
| pubmed:affiliation |
Institute of Clinical Biochemistry, Rikshospitalet, Oslo, Norway.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|