Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-12-18
pubmed:abstractText
FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Caffeic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Cinnamates, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Eugenol, http://linkedlifedata.com/resource/pubmed/chemical/Flavanones, http://linkedlifedata.com/resource/pubmed/chemical/FtsZ protein, Bacteria, http://linkedlifedata.com/resource/pubmed/chemical/Polymers, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/caffeic acid, http://linkedlifedata.com/resource/pubmed/chemical/cinnamic acid, http://linkedlifedata.com/resource/pubmed/chemical/naringenin
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0019-5189
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
783-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ.
pubmed:affiliation
Department of Biochemistry, The Institute of Science, 15 Madame Cama Road, Mumbai 400 032, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't