|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6339
|
|
pubmed:dateCreated |
1991-10-3
|
|
pubmed:abstractText |
The number of lymphocytes in an animal is remarkably constant despite antigen-driven proliferation and a high rate of B-cell lymphopoiesis. This reflects the relatively brief lifespan of many newly generated B cells and argues for a well-regulated death mechanism. Even so, a secondary immune response can be generated years after a primary exposure to antigen. Antigen that might restimulate B cells persists for extended periods on follicular dendritic cells in the light zone of germinal centres. Antigen-binding B cells have also been found months after the end of obvious cell division. The precise signal that enables certain B cells to emerge as long-term surviving memory cells is unknown. Bcl-2, an inner mitochondrial membrane protein, blocks programmed cell death in B cells. We report here that this proto-oncogene maintains immune responsiveness. Transgenic mice overproducing Bcl-2 have a long-term persistence of immunoglobulin-secreting cells and an extended lifetime for memory B cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescein-5-isothiocyanate,
http://linkedlifedata.com/resource/pubmed/chemical/Fluoresceins,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Hemocyanin,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/keyhole-limpet hemocyanin
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
353
|
|
pubmed:geneSymbol |
bcl-2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
71-3
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1908951-Animals,
pubmed-meshheading:1908951-Antigens,
pubmed-meshheading:1908951-B-Lymphocytes,
pubmed-meshheading:1908951-Cell Survival,
pubmed-meshheading:1908951-Fluorescein-5-isothiocyanate,
pubmed-meshheading:1908951-Fluoresceins,
pubmed-meshheading:1908951-Fluorescent Dyes,
pubmed-meshheading:1908951-Hemocyanin,
pubmed-meshheading:1908951-Immunization,
pubmed-meshheading:1908951-Immunization, Passive,
pubmed-meshheading:1908951-Immunoglobulin G,
pubmed-meshheading:1908951-Immunoglobulin M,
pubmed-meshheading:1908951-Immunologic Memory,
pubmed-meshheading:1908951-Kinetics,
pubmed-meshheading:1908951-Mice,
pubmed-meshheading:1908951-Mice, Transgenic,
pubmed-meshheading:1908951-Proto-Oncogene Proteins,
pubmed-meshheading:1908951-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:1908951-Thiocyanates
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Bcl-2 maintains B cell memory.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Washington University School of Medicine, Saint Louis, Missouri 63110.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
