Linked Life Data

19086459

Source:http://linkedlifedata.com/resource/pubmed/id/19086459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-12-17
pubmed:abstractText
Two blood tests have been developed that detect tuberculosis (TB) infection by measuring in vitro T-cell interferon (IFN) -gamma release in response to unique antigens that are highly specific to Mycobacterium tuberculosis. One assay, the enzyme-linked immunospot (ELISpot) [T-SPOT, TB; Oxford Immunotec; Oxford, UK], enumerates IFN-gamma-secreting T cells, while the other measures IFN-gamma concentration in the supernatant by enzyme-linked immunosorbent assay (ELISA) [QuantiFERON-TB Gold; Cellesist, Carnegie, Australia]. Clinical evidence indicates that both tests are more specific than the century-old tuberculin skin test (TST) because they are not influenced by prior Bacille Calmette-Guerin vaccination. Meta-analysis shows that pooled specificity was 97.7% and 92.5% for QFT and Elispot, respectively, and the sensitivity of these tests was suboptimal when newly diagnosed active tuberculosis was used as a surrogate for latent TB infection. These tests are considered to be superior to TST and will replace it for detecting TB infection.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0047-1860
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1026-33
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Specific immune-based diagnosis of tuberculosis infection].
pubmed:affiliation
National Hospital Organization, Tokyo National Hospital, Kiyose, Tokyo 204-8585, Japan. yotumoto@tokyo.hosp.go.jp
pubmed:publicationType
Journal Article, English Abstract, Review