Linked Life Data

19084612

Source:http://linkedlifedata.com/resource/pubmed/id/19084612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-16
pubmed:abstractText
Gray matter heterotopia are a common cause of pharmacoresistant epilepsy. Recently, several case studies have addressed the question of whether heterotopia can contribute to physiological cerebral functions. We describe two cases that demonstrate a functional role for periventricular heterotopia in higher cognitive processes. During presurgical diagnostics, two patients underwent electric stimulation of both the periventricular heterotopia and the overlying cortex. This revealed a functional role of periventricular heterotopia in higher cerebral functions such as language and complex visual and acoustic processing. Furthermore, stimulation of the overlying cortex led to unusually intense positive phenomena, including complex acoustic and gustatory hallucinations and language production. These cases illustrate that periventricular heterotopic neurons can contribute to higher cerebral functions. Interestingly, the anterior-to-posterior representation of these functions is comparable to the normal anterior-to-posterior representation in a normal neocortex (similar to a periventricular "minicortex" in early developmental stages).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1525-5069
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Electric stimulation of periventricular heterotopia: participation in higher cerebral functions.
pubmed:affiliation
Department of Epileptology, University of Bonn, Bonn, Germany. jan.wagner@ukb.uni-bonn.de
pubmed:publicationType
Journal Article, Case Reports