Linked Life Data

19084435

Source:http://linkedlifedata.com/resource/pubmed/id/19084435

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19084435rdf:typepubmed:Citationlld:pubmed
pubmed-article:19084435lifeskim:mentionsumls-concept:C0007634lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C0599840lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C0026724lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C0021853lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C0013126lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C1423038lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C1416941lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C0439662lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C0033268lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C1999230lld:lifeskim
pubmed-article:19084435lifeskim:mentionsumls-concept:C1880266lld:lifeskim
pubmed-article:19084435pubmed:issue6lld:pubmed
pubmed-article:19084435pubmed:dateCreated2008-12-22lld:pubmed
pubmed-article:19084435pubmed:abstractTextNatural killer (NK) cells are innate lymphocytes with spontaneous antitumor activity, and they produce interferon-gamma (IFN-gamma) that primes immune responses. Whereas T helper cell subsets differentiate from naive T cells via specific transcription factors, evidence for NK cell diversification is limited. In this report, we characterized intestinal lymphocytes expressing the NK cell natural cytotoxicity receptor NKp46. Gut NKp46+ cells were distinguished from classical NK cells by limited IFN-gamma production and absence of perforin, whereas several subsets expressed the nuclear hormone receptor retinoic acid receptor-related orphan receptor t (RORgammat) and interleukin-22 (IL-22). Intestinal NKp46+IL-22+ cells were generated via a local process that was conditioned by commensal bacteria and required RORgammat. Mice lacking IL-22-producing NKp46+ cells showed heightened susceptibility to the pathogen Citrobacter rodentium, consistent with a role for intestinal NKp46+ cells in immune protection. RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces.lld:pubmed
pubmed-article:19084435pubmed:languageenglld:pubmed
pubmed-article:19084435pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:citationSubsetIMlld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19084435pubmed:statusMEDLINElld:pubmed
pubmed-article:19084435pubmed:monthDeclld:pubmed
pubmed-article:19084435pubmed:issn1097-4180lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:LochnerMatthi...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:Cerf-Bensussa...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:Di...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:MandelboimOfe...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:SawaShinichir...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:VosshenrichCh...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:MentionJean-J...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:EberlGerardGlld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:ThiamKaderKlld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:Lesjean-Potti...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:RattisFrederi...lld:pubmed
pubmed-article:19084435pubmed:authorpubmed-author:Satoh-Takayam...lld:pubmed
pubmed-article:19084435pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19084435pubmed:day19lld:pubmed
pubmed-article:19084435pubmed:volume29lld:pubmed
pubmed-article:19084435pubmed:ownerNLMlld:pubmed
pubmed-article:19084435pubmed:authorsCompleteYlld:pubmed
pubmed-article:19084435pubmed:pagination958-70lld:pubmed
pubmed-article:19084435pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:meshHeadingpubmed-meshheading:19084435...lld:pubmed
pubmed-article:19084435pubmed:year2008lld:pubmed
pubmed-article:19084435pubmed:articleTitleMicrobial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.lld:pubmed
pubmed-article:19084435pubmed:affiliationCytokines and Lymphoid Development Unit, Institut Pasteur, Paris F-75724, France.lld:pubmed
pubmed-article:19084435pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19084435pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:15978entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:16161entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:16168entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:16185entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:16186entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:16193entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:17086entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:18646entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:19374entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:19885entrezgene:pubmedpubmed-article:19084435lld:entrezgene
entrez-gene:50929entrezgene:pubmedpubmed-article:19084435lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:19084435lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:19084435lld:pubmed
More...