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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0013126,
umls-concept:C0021853,
umls-concept:C0026724,
umls-concept:C0033268,
umls-concept:C0439662,
umls-concept:C0599840,
umls-concept:C1416941,
umls-concept:C1423038,
umls-concept:C1880266,
umls-concept:C1999230
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pubmed:issue |
6
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pubmed:dateCreated |
2008-12-22
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pubmed:abstractText |
Natural killer (NK) cells are innate lymphocytes with spontaneous antitumor activity, and they produce interferon-gamma (IFN-gamma) that primes immune responses. Whereas T helper cell subsets differentiate from naive T cells via specific transcription factors, evidence for NK cell diversification is limited. In this report, we characterized intestinal lymphocytes expressing the NK cell natural cytotoxicity receptor NKp46. Gut NKp46+ cells were distinguished from classical NK cells by limited IFN-gamma production and absence of perforin, whereas several subsets expressed the nuclear hormone receptor retinoic acid receptor-related orphan receptor t (RORgammat) and interleukin-22 (IL-22). Intestinal NKp46+IL-22+ cells were generated via a local process that was conditioned by commensal bacteria and required RORgammat. Mice lacking IL-22-producing NKp46+ cells showed heightened susceptibility to the pathogen Citrobacter rodentium, consistent with a role for intestinal NKp46+ cells in immune protection. RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Natural Cytotoxicity Triggering...,
http://linkedlifedata.com/resource/pubmed/chemical/Ncr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Rorc protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-22
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1097-4180
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pubmed:author |
pubmed-author:Cerf-BensussanNadineN,
pubmed-author:Di SantoJames PJP,
pubmed-author:EberlGerardG,
pubmed-author:Lesjean-PottierSarahS,
pubmed-author:LochnerMatthiasM,
pubmed-author:MandelboimOferO,
pubmed-author:MentionJean-JacquesJJ,
pubmed-author:RattisFrederiqueF,
pubmed-author:Satoh-TakayamaNaokoN,
pubmed-author:SawaShinichiroS,
pubmed-author:ThiamKaderK,
pubmed-author:VosshenrichChristian A JCA
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
958-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19084435-Animals,
pubmed-meshheading:19084435-Antigens, Ly,
pubmed-meshheading:19084435-Citrobacter rodentium,
pubmed-meshheading:19084435-Enterobacteriaceae Infections,
pubmed-meshheading:19084435-Immunity, Innate,
pubmed-meshheading:19084435-Immunity, Mucosal,
pubmed-meshheading:19084435-Interleukins,
pubmed-meshheading:19084435-Intestines,
pubmed-meshheading:19084435-Killer Cells, Natural,
pubmed-meshheading:19084435-Mice,
pubmed-meshheading:19084435-Mice, Inbred C57BL,
pubmed-meshheading:19084435-Mice, Knockout,
pubmed-meshheading:19084435-Natural Cytotoxicity Triggering Receptor 1,
pubmed-meshheading:19084435-Nuclear Receptor Subfamily 1, Group F, Member 3,
pubmed-meshheading:19084435-Perforin,
pubmed-meshheading:19084435-Receptors, Retinoic Acid,
pubmed-meshheading:19084435-Receptors, Thyroid Hormone,
pubmed-meshheading:19084435-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense.
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pubmed:affiliation |
Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F-75724, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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