Source:http://linkedlifedata.com/resource/pubmed/id/19083400
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
Oxidative stress is recognized widely as being associated with various disorders including diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing action. We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We performed a randomized, double-blind, placebo-controlled, crossover study in 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT. The patients consumed either 900 mL/d of hydrogen-rich pure water or 900 mL of placebo pure water for 8 weeks, with a 12-week washout period. Several biomarkers of oxidative stress, insulin resistance, and glucose metabolism, assessed by an oral glucose tolerance test, were evaluated at baseline and at 8 weeks. Intake of hydrogen-rich water was associated with significant decreases in the levels of modified low-density lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15.5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase. In 4 of 6 patients with IGT, intake of hydrogen-rich water normalized the oral glucose tolerance test. In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1879-0739
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pubmed:author |
pubmed-author:AdachiTetsuoT,
pubmed-author:AsanoMaiM,
pubmed-author:FukuiMichiakiM,
pubmed-author:HasegawaGojiG,
pubmed-author:HosodaHirokoH,
pubmed-author:ImaiSaekoS,
pubmed-author:KajiyamaSizuoS,
pubmed-author:KitawakiJoJ,
pubmed-author:NakamuraNaotoN,
pubmed-author:NakanoKojiK,
pubmed-author:ObayashiHiroshiH,
pubmed-author:OhtaMitsuhiroM,
pubmed-author:YoshikawaToshikazuT
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-43
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pubmed:meshHeading |
pubmed-meshheading:19083400-Biological Markers,
pubmed-meshheading:19083400-Blood Glucose,
pubmed-meshheading:19083400-Cross-Over Studies,
pubmed-meshheading:19083400-Diabetes Mellitus, Type 2,
pubmed-meshheading:19083400-Dietary Supplements,
pubmed-meshheading:19083400-Double-Blind Method,
pubmed-meshheading:19083400-Female,
pubmed-meshheading:19083400-Glucose Intolerance,
pubmed-meshheading:19083400-Glucose Tolerance Test,
pubmed-meshheading:19083400-Humans,
pubmed-meshheading:19083400-Hydrogen,
pubmed-meshheading:19083400-Lipid Metabolism,
pubmed-meshheading:19083400-Male,
pubmed-meshheading:19083400-Middle Aged,
pubmed-meshheading:19083400-Oxidative Stress,
pubmed-meshheading:19083400-Treatment Outcome,
pubmed-meshheading:19083400-Water
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pubmed:year |
2008
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pubmed:articleTitle |
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
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pubmed:affiliation |
Kajiyama Clinic, Kyoto 615-0035, Japan.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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