Linked Life Data

19082920

Source:http://linkedlifedata.com/resource/pubmed/id/19082920

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-12-23
pubmed:abstractText
Mast cells are important effector cells in allergic inflammatory reactions. The aggregation of the high-affinity IgE receptor (FcepsilonRI) on the surface of mast cells initiates a complex cascade of signaling events that ultimately leads to the release of various mediators involved in allergic inflammation and anaphylactic reactions. The release of these mediators is tightly controlled by signaling pathways that are propagated through the cell by specific phosphorylation and dephosphorylation events. These events are controlled by protein kinases and protein phosphatases which either positively or negatively regulate the propagation of the signal through the cell. This review summarizes the role of both positive and negative regulators of FcepsilonRI-induced mast cell activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1661-4917
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-99
pubmed:meshHeading
pubmed:articleTitle
Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation.
pubmed:affiliation
Department of Microbiology and Immunology, Dalhousie University, 5850 University Ave., Halifax, NS, Canada B3K6R8.
pubmed:publicationType
Journal Article, Review