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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-9-18
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pubmed:abstractText |
Low density lipoprotein and its oxidized form has been implicated in the process of arteriosclerosis which involves growth-related events in the smooth muscle cells of the arterial wall. The induction of so-called early-growth response genes e.g. c-myc and c-fos can serve as an indicator for these growth-related events. In cultured human vascular smooth muscle cells, both LDL and HDL3 were individually capable of stimulating c-myc and c-fos expression in a concentration dependent manner. However, when they were used in combination, depending on the proportion of HDL3 to LDL, c-fos but not c-myc expression was less pronounced than with the single components. In contrast to HDL3 and LDL alone, a combination of the two lipoproteins also blunted both the expression of autoinduced transforming growth factor beta transcripts and the transforming growth factor beta-induced increase of c-fos mRNA. It is concluded that a) the inhibition of transforming growth factor beta autostimulation by HDL3 plus LDL may involve reduced AP-1 activity via a reduction of c-fos expression by the lipoprotein combination and b) the ratio HDL3:LDL might influence the pathogenesis of arteriosclerosis via growth-related events in the arterial wall.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL3,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
178
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pubmed:geneSymbol |
c-fos,
c-myc
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1465-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1908239-Arteries,
pubmed-meshheading:1908239-Blotting, Northern,
pubmed-meshheading:1908239-Cells, Cultured,
pubmed-meshheading:1908239-Gene Expression,
pubmed-meshheading:1908239-Genes, MHC Class I,
pubmed-meshheading:1908239-Genes, myc,
pubmed-meshheading:1908239-Humans,
pubmed-meshheading:1908239-Kinetics,
pubmed-meshheading:1908239-Lipoproteins, HDL,
pubmed-meshheading:1908239-Lipoproteins, HDL3,
pubmed-meshheading:1908239-Lipoproteins, LDL,
pubmed-meshheading:1908239-Muscle, Smooth, Vascular,
pubmed-meshheading:1908239-Protein-Tyrosine Kinases,
pubmed-meshheading:1908239-Proto-Oncogene Proteins,
pubmed-meshheading:1908239-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:1908239-Proto-Oncogenes,
pubmed-meshheading:1908239-RNA, Messenger,
pubmed-meshheading:1908239-Transcription, Genetic,
pubmed-meshheading:1908239-Transforming Growth Factor beta
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pubmed:year |
1991
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pubmed:articleTitle |
Modulation of gene expression by high and low density lipoproteins in human vascular smooth muscle cells.
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pubmed:affiliation |
Department of Research, Basel University Hospital, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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