Linked Life Data

19082045

Source:http://linkedlifedata.com/resource/pubmed/id/19082045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
43
pubmed:dateCreated
2008-12-16
pubmed:abstractText
New Pt(ii) and Pd(ii) complexes with the metal center coordinated to two different chelating ligands, tropolone (trop) and dihexadecyl-2,2'-bipyridine-4,4'-dicarboxylate bipyridine (bipy), [(bipy)M(trop)][CF(3)SO(3)], have been synthesized and their biological evaluation has been performed demonstrating a remarkable cytotoxic activity in vitro against the human prostate DU145 and hormone-sensitive LNCaP cells lines. Moreover, for the Pt(ii) derivative, the molecular structure has been determined by single-crystal X-ray diffraction and computational analysis on the hydrolysis reaction mechanisms have been performed by density functional theory (DFT) calculations, in order to correlate molecular structure, biological activity and mechanism of action of this new class of complexes based on two different bioactive fragments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1477-9226
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5897-904
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Bioactive fragments synergically involved in the design of new generation Pt(ii) and Pd(ii)-based anticancer compounds.
pubmed:affiliation
Centro di Eccellenza CEMIF, CAL-LASCAMM, Unità INSTM della Calabria, Dipartimento di Chimica Università della Calabria, 87030, Arcavacata di Rende (CS), Italy. d.pucci@unical.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't