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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
The chronic pathological changes in vascular walls of hypertension may exert destructive effects on multiple organ systems. Accumulating evidence indicates that inflammatory reactions are involved in the pathological changes of hypertension. Three peroxisome proliferator-activated receptors (PPARs) have been identified: PPARalpha, PPARbeta/delta, and PPARgamma, all of which have multiple biological effects, especially the inhibition of inflammation. The aim of this study was to evaluate PPAR isoforms expression profile in important organs of spontaneously hypertensive rats (SHR) and to understand the modulation of endogenous PPAR isoforms under inflammatory condition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0366-6999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2305-11
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pubmed:meshHeading |
pubmed-meshheading:19080338-Animals,
pubmed-meshheading:19080338-Blood Pressure,
pubmed-meshheading:19080338-Blotting, Western,
pubmed-meshheading:19080338-E-Selectin,
pubmed-meshheading:19080338-Gene Expression,
pubmed-meshheading:19080338-Hypertension,
pubmed-meshheading:19080338-Inflammation,
pubmed-meshheading:19080338-Interleukin-1beta,
pubmed-meshheading:19080338-Male,
pubmed-meshheading:19080338-PPAR alpha,
pubmed-meshheading:19080338-PPAR delta,
pubmed-meshheading:19080338-PPAR gamma,
pubmed-meshheading:19080338-Peroxisome Proliferator-Activated Receptors,
pubmed-meshheading:19080338-Plethysmography,
pubmed-meshheading:19080338-Rats,
pubmed-meshheading:19080338-Rats, Inbred SHR,
pubmed-meshheading:19080338-Rats, Inbred WKY,
pubmed-meshheading:19080338-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19080338-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19080338-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2008
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pubmed:articleTitle |
Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats.
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pubmed:affiliation |
Murad Research Institute for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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